Grande and Venti are different in espresso except americano American coffee. Most drinks only have different amounts of syrup and milk, so the taste of oversized cups will be lighter and more inclined to drinks. Syrup is used for flavoring, and milk is used for …emmm… filling cups. )
In my personal experience, I usually choose medium or large cups according to my demand for caffeine (one of the reasons is that large cups can't be finished).
PS: I want to add here. Starbucks is one of the cheaper things I have seen in foreign countries after exchange rate conversion. (The other one is called Haagen-Dazs. ) So I seldom buy Starbucks after returning to China.