Jejunal stromal tumor is a special type of tumor, which is relatively rare in clinic. Most of the tumors are malignant and tend to be implanted and metastasized. If no metastasis is found at present, the only effective treatment is surgical resection. Complete resection of the primary tumor focus can achieve therapeutic effect, but the probability of recurrence and metastasis after operation is high (but if surgery is not performed, intestinal perforation may be life-threatening due to the continuous growth of tumor). However, the effect of radiotherapy and chemotherapy for stromal tumors is poor, and the effective rate is less than 5%. Now molecular targeted therapy technology is still being explored, but the initial clinical application effect is higher than that of traditional radiotherapy and chemotherapy technology, and it is expected to have better treatment effect in the future! The definition of GIST is constantly changing, and it has just been confirmed that GIST is a tumor with specificity in clinic and histopathology. In the past, GIST was often missed and misdiagnosed because of the confusion of tumor classification, which was similar to other tumor types. At present, it is considered that gastrointestinal stromal tumors are a group of tumors that originated from gastrointestinal mesenchymal stem cells independently, and have clear pathological and immunohistochemical characteristics. It is closely related to the mutation of tyrosine kinase receptor. However, there are no specific preventive measures for this tumor in clinic for the time being!