Instructions for Ginkgo Damol Injection

[Drug Name] Ginkgo Damol Injection,

[Specifications] This product is a compound preparation, each 5ml (bottle) ) contains 4.5 to 5.5 mg of total ginkgo flavonoids and 1.8 to 2.2 mg of dipyridamole; each 10ml (tube) contains 9.0 to 11.0 mg of total ginkgo flavonoids and 3.6 to 4.4 mg of dipyridamole.

[Characteristics] This product is a yellow to brown clear liquid.

[Pharmacology and Toxicology] 1. Pharmacology: The total flavonoids in Ginkgo biloba in this product can expand coronary blood vessels and cerebral blood vessels, and improve cerebral ischemia symptoms and memory function. Dipyridamole inhibits platelet aggregation, and high concentrations (50ug/ml) can inhibit platelet release. The possible mechanism of action is: (1) Inhibiting the uptake of adenosine by platelets, epithelial cells and red blood cells. The inhibitory effect becomes dose-dependent at therapeutic concentrations (0.5-1.9ug/dl). The local adenosine concentration increases, acting on the A2 receptor of platelets, stimulating adenylyl cyclase, and increasing cyclic adenosine monophosphate (cAMP) in platelets. Through this pathway, platelet aggregation caused by stimulation such as platelet activating factor (PAP), collagen, and adenosine diphosphate (ADP) is inhibited. (2) Inhibit phosphodiesterase (PDE) in various tissues. The therapeutic concentration inhibits cyclic guanosine monophosphate phosphodiesterase (cGMP-PDE) and has a weak inhibitory effect on Camp-PDE, thereby enhancing the increase in cGMP concentration caused by endothelial relaxing factor (EDRP). (3) Inhibit the formation of thromboxane A2 (TXA2), which is a powerful agonist of platelet activity. (4) Enhance the effect of endogenous PGI2. This product can slow down the heart rate of anesthetized cats and dogs, has a significant preventive and therapeutic effect on myocardial ischemia caused by coronary artery ligation in cats, and can reduce the scope of myocardial infarction.

2. Toxicology: Long-term toxicity experiments in rats showed that no toxic reactions were seen in three dose groups (125 times, 62.5 times and 31.25 times the human dose) administered intraperitoneally for 30 days.

[Pharmacokinetics] The plasma half-life (t1/2) is 2-3 hours. High binding rate to plasma proteins. Metabolized in the liver, combined with glucuronic acid, and excreted from the bile.

[Indications] Used for the prevention and treatment of coronary heart disease and thromboembolic diseases.

[Usage and Dosage] Intravenous drip. For adults, take 10-25ml at a time, add 0.9% sodium chloride injection or 500ml of 5%--10% glucose injection, twice a day.

[Adverse reactions]

1. Occasionally nausea, vomiting, dizziness, and skin allergic reactions may occur.

2. Rarely, angina pectoris worsens. Once the medication is stopped, the symptoms disappear immediately.

[Precautions] People with bleeding tendency should use with caution.

[Use by pregnant and lactating women] Use with caution by pregnant women.

[Drug Interaction] When used together with anticoagulants such as heparin and dicoumarol, it may easily cause bleeding tendencies.

[Specifications] (1), 5ml (2) 10ml.

〔Storage〕Shield and seal.

[Packaging] 1. 5ml×10 pcs/box, 2. 10ml×5 pcs/box.

[Validity period] Tentatively scheduled for 2 years.

Function description of Ginkgo Damo injection

Ingredients:

Ginkgo flavonoids: 24%

Terpenes: (Ginkgo bitter lactone 3.1%, bilobalide 2.9%)

Dipyridamole: 10%

Comprehensive pharmacological effects:

Regulate the vasodilation function

Scavenge free radicals

Antagonize PAF

Protect neurons

Good efficacy:

Blood flow Adjustment of dynamics: dilation of arterial blood vessels, reduction of blood vessel wall permeability, improvement of edema

Improvement of blood rheology: reduction of ischemic viscosity, inhibition of high aggregation of platelets and red blood cells, and increase of red blood cell deformation Sexuality

Regulation of the cardiovascular system: reduce myocardial oxygen consumption, enhance myocardial cell tolerance to ischemia and hypoxia

Improve tissue metabolism: stabilize cell membranes, maintain normal cells Structure and function

Neuroprotective effect: Directly protect neurons, enhance nerve conduction, and accelerate the renewal of neurotransmitters