Hot at night and cool early means that the fever is low at night, and then it gets cold in the morning. In the late stage of epidemic febrile disease, both qi and yin are consumed, yang deficiency causes early cooling, and yin and body fluid deficiency causes night heat. The representative prescription is Artemisia annua Turtle and Carapax Trionycis Decoction, which is characterized by hot night and early cooling, no sweating, loss of appetite, red tongue with little coating and rapid pulse.

In the late stage of epidemic febrile disease, the heat type of pathogenic factors in yin is night heat and early cooling, which is manifested as night heat and morning retreat. This antipyretic is not sweating, it is not high when it is hot.

Syndrome of evil storing yin is the general name of TCM disease syndromes. It is more common in the late stage of spring fever, which belongs to the syndrome of yin fluid loss and residual pathogens staying in yin points. In the late stage of spring fever, vaginal fluid is deficient, and pathogenic factors stay in Yin points. Key points of syndrome differentiation: Wei Qi moves in Yang during the day, and moves in Yin at night, with excess heat due to yin deficiency, and Wei Qi enters Yin at night to resist evil, so it is hot at night; In the morning, the defensive qi goes out of yin and acts on the exterior, and the evil is indisputable, so the heat recedes and cools, and the residual heat does not go out with the defensive qi, so the heat recedes and there is no sweat;

Pathogen stays in yin, disease is not in gastrointestinal tract, and it can be eaten; If the residual heat stays for a long time, the body will lose weight if the yin qi fails; Red tongue with little coating and rapid pulse are all signs of heat consuming vaginal fluid. Clinical manifestations: night heat and early cooling, fever without sweating, loss of appetite, less red tongue coating and deep and thin pulse. Treatment: nourishing yin and penetrating heat. Prescription: Artemisia annua Biejia Decoction. Commonly used Chinese medicines: Artemisia annua, Carapax Trionycis, Radix Rehmanniae, Rhizoma Anemarrhenae and Cortex Moutan. ?

In the late stage of epidemic febrile disease, the yin fluid is insufficient, and the remaining pathogens stay in the yin, and the yang enters the yin at night, and the yin in the body does not control the yang, resulting in fever. During the day, yang comes from yin, and yin and yang in the body can maintain balance, so it will not be hot. Because this disease is not a superficial disease of fever, sweating and fever. Wu Jutong's Treatise on Febrile Diseases said: "The night is hot and cool early, and the heat goes away without sweat, and the heat comes out of the yin. Artemisia annua Turtle Decoction is used to treat it."