On April 27, 1911, the Guangzhou Uprising broke out, which shocked China and foreign countries. At around 4 o'clock in the afternoon, Huang Xing gathered the uprising team at the general headquarters, issued a general mobilization order, and set off impassionedly.

At 5:30 pm, Huang Xing led 130 people to rush to the Governor's Office of Guangdong and Guangxi. As soon as he walked out of Dongyuan Gate, he encountered the Qing army. The first section of Huang Xing's middle finger and index finger on his right hand were broken by bullets, but he endured the severe pain and used the second section of his finger to press the gun and shoot. A fierce battle began with the enemy. Seeing the increasing number of Qing troops, Huang Xing ordered the rebels to break out in three groups. He led a group of his own to rush out of the south gate and retreat while fighting. He bumped open a closed shop on the street with his shoulder, stretched out two guns from the shop, fired his bow from left to right, and killed seven or eight Qing soldiers. When night approached, the Qing soldiers retreated, and the gunfire fell silent, he washed the wound with cold water, briefly bandaged it, and escaped from the Qing army's encirclement by boat.

The next day, Huang Xing met Zhao Sheng, the leader who came to participate in the uprising, and the two burst into tears. Huang Xing planned to go alone to avenge his comrades who died in the battle, but was stopped by Zhao Sheng and others. On April 29, Huang Xing was escorted by a comrade and sneaked back to Hong Kong for medical treatment. After the failure of the Guangzhou Uprising, the martyrs were collected and 72 bodies were found and buried together in Huanghuagang in the east of the city. Therefore, the uprising was called the "Huanghuagang Uprising."