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Generic Name: MIFEPRISTONE TABLETS
Old Names: MIFEPRISTONE TABLETS
English Name: MIFEPRISTONE TABLETS
Pinyin Name: MIFEISITONG PIAN
This product's main Mifepristone. Its chemical name is: 11b-[4-(N,N-dimethylamino)]phenyl-17b-hydroxy-17a-(1-propynyl)-estra-4,9-dien-3-one.
Molecular formula: C29H35NO2
Molecular weight: 429.61
Drug class: estrogens and progestins
Indications: Mifepristone tablets are used in combination with sequential use of prostaglandin medications to terminate pregnancies within 49 days of menopause.
Properties: This product is a yellowish tablet, odorless and tasteless.
Pharmacology and toxicology: Mifepristone is a receptor level antiprogesterone drug, which has the effect of terminating early pregnancy, resisting implantation, inducing menstruation and promoting cervical ripening, etc. It competes with progesterone for the receptor to achieve the effect of antagonizing progesterone, and also has a certain binding force with glucocorticoid receptor. Mifepristone can significantly increase the sensitivity of the pregnant uterus to prostaglandins. Small doses of mifepristone sequentially combined with prostaglandin analogs can obtain satisfactory results in terminating early pregnancy.
Pharmacokinetics: The oral absorption of this product is rapid, semi-synthetic and synthetic mifepristone blood concentration peak time of 1.5?0.81 hours, respectively, the peak value of the blood drug were 0.8 mg / L and 2.34 mg / L, but there are obvious individual differences. Elimination is slow, with an elimination half-life of about 20?34 hours. The blood level can be maintained at about 0.2 mg/L for 72 hours after administration. This product has a significant first-pass effect, 1?2 hours after oral blood metabolite levels can already exceed the parent compound.
Use and dosage: ≤ 49 days of menopause in healthy women with early pregnancy, fasting or 2 hours after eating, oral 25?50 mg mifepristone tablets twice a day for 2?3 days, the total amount of 150 mg, fasting for two hours after each dose, the third?4 days of the early morning in the posterior vault of the vagina to place the carboprost methyl suppository 1 pessary (1mg), or the use of other similar prostaglandin drugs. Bed rest for 1?2 hours and outpatient observation for 6 hours. Watch for bleeding after medication, any pregnancy products and side effects.
Adverse reactions: 1. Some women with early pregnancy have mild nausea, vomiting, dizziness, fatigue and lower abdominal pain, anal cramping and uterine bleeding after taking the drug. 2. Individual women may develop a rash. 3. there may be abdominal pain with prostaglandins, vomiting and diarrhea in some subjects. A few have flushing and tingling.
Contraindications: 1. hypersensitivity to the product. 2. patients with cardiac, hepatic and renal diseases and adrenocortical insufficiency. 3. people with contraindications to the use of prostaglandin drugs: such as glaucoma, asthma and allergy to prostaglandin drugs. 4. pregnancy with intrauterine device and suspected ectopic pregnancy, smoking women over 35 years old.
Precautions: 1. For those who are confirmed to be early pregnant, the days of menopause should not be more than 49 days, and the shorter the gestation period, the better the effect. 2. mifepristone tablets must be used in conditions with emergency, curettage procedures and transfusion of fluids and blood. This medication must not be sold on its own at a pharmacy. 3. Before taking the medicine, the person taking the medicine must be informed in detail of the therapeutic effects, and possible side effects. If heavy bleeding or other abnormalities occur during treatment or follow-up, seek medical attention. 4. A small amount of vaginal bleeding usually occurs earlier after taking the drug, and some women have prolonged bleeding after miscarriage. A small number of early pregnant women can have a spontaneous abortion after taking mifepristone tablets. About 80% of pregnant women expelled chorionic follicles within 6 hours after the use of prostaglandin analogs, and about 10% of pregnant women expelled the pregnancy within one week after taking the drug. 5. 8 to 15 days after taking the drug should go to the original treatment unit for follow-up to determine the effect of abortion. If necessary, B-type ultrasonography or blood HCG measurement should be made. If the diagnosis of incomplete abortion or continued pregnancy is confirmed, it should be treated in time. 6. If the use of this product to terminate early pregnancy fails, abortion must be performed to terminate the pregnancy.
Pregnant women and lactating women: prohibited except for the termination of early pregnancy women.
Children:
Elderly patients:
Drug interactions: Avoid aspirin and other nonsteroidal anti-inflammatory drugs within 1 week of taking this product.
Overdose:
Storage: Store in a dry place, protected from light.
The shopping guide said that the side effects of the one-piece mifepristone tablets than the two-piece Yutin side effects to be smaller because a piece of the installed profits than the two-piece installed to be much higher, a piece of the installed profits only a few cents of the installed profits of the two-piece installed a few dollars, is an individual will be so said. Regardless of whether it's a one-piece package two-piece package Yuktim, golden Yuktim, after the Dingnuo and so on, as long as it is Mifepristone emergency contraceptive pills class of side effects are the same. Emergency contraceptives can't be taken more than two times a month, which can cause endocrine disruption, so it's recommended to wear a condom, and too much of it can easily cause infertility. The first time you take it, it won't affect your fertility.
This medicine is used as little as possible. The first time you take it, you're going to have to take it with a condom, so you're going to have to take it with a condom, and you're going to have to take it with a condom. It is true that this drug is an abortion pill, but I heard that the contraceptive effect is good. However, I don't know what the rate of certainty is. I am also very worried, because this is the second time I take this drug, it is better to take it less in the future, it will definitely have an impact on the body. I'm not sure what the rate of certainty is, but I'm worried. The woman, the body, is the first.
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