Table of Contents 1 Pinyin 2 English Reference 3 General Introduction 4 Effects and Indications of Andrographis paniculata Tablets 5 Pharmacopoeial Standard of Andrographis paniculata Tablets 5.1 Name 5.2 Prescription 5.3 Method of Preparation 5.4 Characteristics 5.5 Identification 5.6 Examination 5.7 Content Determination 5.7.1 Chromatographic Conditions and System Suitability Tests 5.7.2 Preparation of Reference Solution 5.7.3 Preparation of Supplementary Solution 5.7.4 Method of Measurement 5.8 Functions and Indications 5.9 Methods and Dosage 5.10 Storage 5.11 Version 5.8 Functions and Indications 5.9 Usage and Dosage 5.10 Storage 5.11 Version 6. 6.1 Name of the Drug 6.2 Hanyu Pinyin of the Drug 6.3 Formulations 6.4 Properties 6.5 Main Ingredients of Andrographis Paniculata 6.6 Functions and Indications of Andrographis Paniculata 6.7 Usage and Dosage of Andrographis Paniculata 6.8 Adverse Reactions to Andrographis Paniculata 6.9 Precautions 6.10 Interaction between Andrographis Paniculata and Other Drugs 6.11 Remarks 7. 6.11 Remarks 7 References Attachment: 1 Chuanxinlian Tablets in Ancient Books * Other versions of Chuanxinlian Tablets 1 Pinyin

chuān xīn lián piàn

2 English Reference

chuanxinlian tablets [Nomenclature of Traditional Chinese Medicine (2004): Chuanxinlian Tablets, Chinese Medicine (2004): Chuanxinlian Tablets, Chinese Medicine (2004): Chuanxinlian Tablets]. Chinese Medicine Nomenclature (2004)]

chuanxinlian pian [Chinese Medicine Nomenclature Validation Committee. Nomenclature of Chinese Medicine (2004)]

3 Overview

Chuanxinlian Pian is a Chinese patent medicine, which is a tablet made of Andrographis paniculata by processing [1]. It has the efficacy of clearing heat and removing toxins, cooling blood and subduing swelling. It is used in the treatment of evil toxicity, cold and fever, sore throat, mouth and tongue, cough and cough, diarrhea and dysentery, fever and astringent pain, carbuncle and swollen sores, and poisonous snake bites.

4 The efficacy and main treatment

The penetrating lotus tablets have the effect of clearing away heat and detoxification, cooling the blood and eliminating swelling. It can be used in the treatment of evil toxicity, cold and fever, sore throat, mouth and tongue, cough and cough, diarrhea and dysentery, fever and astringent pain, carbuncle and sores, snake bites.

Andrographis paniculata tablets have the effect of clearing heat and detoxification, used to treat sore throat, surgical sores, etc.[2].

5 Pharmacopoeia standard of Chuanxinlian Pian 5.1 Name

Chuanxinlian Pian

Chuanxinlian Pian

5.2 Prescription

Chuanxinlian Pian 1000g

5.3 Preparation

Take Chuanxinlian Pian and extract it twice by hot immersion in 85% ethanol for two hours each time, then merge the extracts and filter them, then recover the ethanol in filtrate, concentrate them to the right amount, dry them, add appropriate amount of auxiliaries and make granules. Add the appropriate amount of auxiliary materials, made of granules, dry, pressed into 1000 tablets (small tablets) or 500 tablets (large tablets), sugar coated or film coated, that is obtained.

5.4 Character

This product is sugar-coated or film-coated tablets, gray-brown to brown after removing the coating; bitter taste.

5.5 Identification

Take the filtrate under [Content Determination] as the test solution. Take 0.5g of Andrographis paniculata control herb, add 30ml of methanol, ultrasonic treatment for 30 minutes, filtration, the filtrate was concentrated to about 5ml, as the control herb solution. Then take the dehydrated Andrographis paniculata lactone control, add methanol to make a solution containing 1mg per 1ml, as the control solution. According to thin-layer chromatography (2010 Pharmacopoeia, Appendix VI B), absorb 5μl of each of the above three solutions, respectively, on the same silica gel GF254 thin-layer plate, trichloromethane - ethyl acetate - methanol (20:15:2) as an unfolding agent, unfolded at 28 ℃, remove, and let dry. Under the ultraviolet light (254nm), in the chromatogram of the test article, in the corresponding position with the chromatogram of the control herb and the control article, the spots of the same color were shown; sprayed with 2% 3,5 dinitrobenzoic acid ethanol solution and 2mol/L potassium hydroxide solution in equal volume of the mixture (prepared for clinical use), and then immediately examined under the sunlight. In the chromatogram of the test product, in the corresponding position with the chromatogram of the control herb and the chromatogram of the control product, the spot of the same color.

5.6 Inspection

It should comply with the relevant provisions under tablets (2010 version of Pharmacopoeia I Appendix I D).

5.7 Determination of content

Determined by high performance liquid chromatography (2010 Pharmacopoeia, Appendix VI D).

5.7.1 Chromatographic conditions and system suitability test

Octadecylsilane-bonded silica gel was used as filler; methanol-water (60:40) was used as the mobile phase; the detection wavelength was 254 nm; the theoretical plate number should not be less than 2,000 based on the peaks of the dehydrated andrographis paniculata lactone.

5.7.2 Preparation of the control solution

An appropriate amount of the control product of dehydrated andrographis paniculata lactone was taken.

Take the appropriate amount of dehydrated Andrographolide control product, precision weighing, add methanol to make a solution containing 0.1mg per 1ml, that is obtained.

5.7.3 Preparation of test solution

Take 20 tablets (small tablets) or 10 tablets (large tablets), remove the coating, precision weighing, research fine, take 0.5g, precision weighing, placed in a stoppered conical flask, precision add 25ml of methanol, tightly stoppered, weighed, immersed in 1 hour, ultrasonic treatment (power 250W, frequency 33kHz) for 30 minutes, cooled, and then weighed. Make up the lost weight with methanol, shake well, filtered, precision measure 10ml of filtrate (the remaining filtrate for backup), added to the neutral alumina column (200-300 mesh, 5g, inner diameter of 1.5cm), eluted with 20ml of methanol, collect the eluent, placed in a 50ml measuring flask, add methanol to the scale, shaking, that is, obtained.

5.7.4 Determination

Precisely aspirate 10μl each of the control solution and test solution separately, inject into the liquid chromatograph, determination, that is, obtained.

Each tablet of this product contains dehydrated Andrographis paniculata lactone (C20H28O4), the small tablets shall not be less than 4.0mg, the large tablets shall not be less than 8.0mg.

5.8 Functions and Indications

Clearing away heat and removing toxins, cooling the blood to eliminate swelling. It is used for the internal exuberance of evil poison, cold and fever, sore throat, mouth and tongue sores, cough and cough, diarrhea and dysentery, hot showers and astringent pain, carbuncle, swelling and ulcers, and poisonous snake bites.

5.9 Dosage and Administration

Oral. 2-3 tablets (small tablets), 3-4 times a day; or l-2 tablets (large tablets), 3 times a day.

5.10 Storage

Sealed.

5.11 Version

Chinese Pharmacopoeia of the People's Republic of China, 2010 Edition

6 Chuanxinlian Tablets 6.1 Name

Chuanxinlian Tablets

6.2 Hanyu Pinyin

Chuanxinlian Pian

6.3 Formulations

Sugar-coated or thin-film-coated tablets

6.4 Characteristics

Chuanxinlian Tablets are sugar-coated tablets or thin-film-coated tablets, which can be removed by removing the coating. After removing the coating, it appears gray-brown to brown; bitter taste.

6.5 Main ingredients of Andrographis paniculata Tablets

Andrographis paniculata.

6.6 Functions of Andrographis paniculata Tablets

Clearing away heat and removing toxins, cooling the blood and subduing swelling. It can be used in the treatment of internal toxicity, cold and fever, sore throat, mouth and tongue, cough and cough, diarrhea and dysentery, hot showers and astringent pain, carbuncle and swollen sores, and poisonous snake bites.

6.7 Usage and dosage of Andrographis paniculata tablets

Oral. 2-3 tablets (small tablets), 3-4 times a day; or l-2 tablets (large tablets), 3 times a day.

6.8 Adverse effects of Andrographis paniculata

Andrographis paniculata can cause nausea, vomiting, lack of appetite. Occasionally, allergic reactions occur.

6.9 Precautions

1. Avoid tobacco, alcohol, spicy, fishy food.

2. It is not advisable to take tonic Chinese medicine at the same time during the medication.

3. People with high blood pressure, heart disease, liver disease, diabetes, kidney disease and other chronic diseases should take under the guidance of a physician.

4. Children, pregnant women, lactating women, the elderly and weak, spleen and loose stools should be taken under the guidance of a physician.

5. If the symptoms are not relieved after 3 days of taking the medicine, you should go to the hospital.

6. Allergic to the product is prohibited, allergic people should be cautious.

7. The use of this product is prohibited when the properties of the product have changed.

8. Children must be used under adult supervision.

9. Keep this product out of the reach of children.

10. If you are using other drugs, consult your physician or pharmacist before using this product.

6.10 Drug interactions

Drug interactions may occur if used with other medications, consult your physician or pharmacist for details.

6.11 Remarks