Efficacy of Polygonum multiflorum Thunb: 1. Antioxidant effect Polygonum multiflorum Thunb can increase the content of SOD (Superoxide Dismutase) in blood, brain and liver tissues of elderly animals, decrease LPO (Plasma Lipid Peroxide), increase the antioxidant capacity, and significantly resist the decrease of SOD content in blood caused by Bupleurum chinense or hydrocortisone. Animal experiments show that Polygonum multiflorum Thunb can reduce the content of MDA in the brain and liver of mice. Polygonum multiflorum decoction can significantly reduce LPO in plasma and liver of aged rats and improve hemorheological indexes. Polygonum multiflorum pill can obviously reduce the content of lipofuscin in brain tissue and scavenge superoxide anion free radicals. 2. Inhibition of monoamine oxidase B (MAO-B) activity MAO-B can indirectly reflect the aging degree of organisms. Aging is often accompanied by the increase of MBO-B activity and the decrease of monoamine transmitter content in the brain. Animal experiments show that Polygonum multiflorum Thunb can obviously inhibit MBO-B in brain and liver, and also significantly increase the contents of 5-hydroxytryptamine (5-HT), norepinephrine (NE) and dopamine (DA) in the brain of old mice, thus exerting its anti-aging effect. 3. Increasing immune function The alcohol extract or water extract of Polygonum multiflorum Thunb can increase the content of cytoplasmic protein and nucleic acid in thymocytes of old mice, increase the specific gravity and weight of thymocytes of old mice, promote the proliferation of thymocytes, and delay age-related degenerative atrophy. Polygonum multiflorum decoction can increase the density of thymocytes in aged mice, and the nuclear and intracellular structures obviously return to normal or close to normal. Injecting the ethanol extract of Polygonum multiflorum Thunb. into the abdominal cavity of mice can significantly improve the thymocyte proliferation induced by sword bean A(conA). Polygonum multiflorum Thunb can increase γ -globulin content in mice, activate macrophages and lymphocytes, increase lymphocyte transformation rate, induce interferon production, and obviously promote cellular immunity and regulate humoral immunity in immunosuppressed mice. 4. Enhancing Hematopoietic Function: Polygonum multiflorum Thunb extract (PM-2) can increase the number of hematopoietic stem cells in mouse bone marrow, the number of bone marrow granulosa-monocytic progenitor cells and erythroid progenitor cells, and the proportion of reticulocytes in peripheral blood, which shows that PM-2 can significantly promote a variety of bone marrow hematopoietic cells and can fully act on the hematopoietic system. It is suggested that the mechanism of Polygonum multiflorum Thunb in nourishing blood, benefiting liver and tonifying kidney lies in strengthening the proliferation of hematopoietic progenitor cells in bone marrow, thus having the function of strengthening and prolonging life. 5. Hypolipidemic effect Animal experiments show that Polygonum multiflorum decoction can reduce the serum cholesterol (TC) level of normal rats, significantly reduce the area and degree of atherosclerosis (AS) of main arteries in rabbits fed with high-fat diet, significantly reduce the number of coronary artery lesions and lumen blockages, lower the contents of lipofuscin and LPO in AS plaques in heart, brain and kidney tissues, and lower the levels of serum TC and β-lipoprotein. In vitro experiments show that Polygonum multiflorum Thunb can combine with cholesterol and reduce the deposition of cholesterol in the body. Some people think that lecithin in Polygonum multiflorum Thunb can prevent cholesterol from depositing in the liver, promote the oxidation of cholesterol into cholic acid, and prevent lipid-like substances from staying in the serum and penetrating into the intima. The hypolipidemic effect of Polygonum multiflorum Thunb is also one of its anti-aging mechanisms. Six, other effects Polygonum multiflorum Thunb has the effect of strengthening the heart and increasing coronary blood flow. Among them, the extract of an anthraquinone derivative can promote hair growth and blackening white hair. In addition, its cold resistance and sedation play an important role in delaying aging. Longevity, black beard and black hair are a major feature of Polygonum multiflorum Thunb. Its curative effect is conclusive and people have always attached great importance to it. For example, "Kaibao Materia Medica" contains: "Polygonum multiflorum Thunb. has long bones and muscles, benefits the essence, and prolongs life." In the Ming Dynasty, Li Shizhen called Ji "warm and bitter in nature, bitter can tonify kidney and liver, astringent can converge essence, so it can nourish blood and liver, strengthen industry and kidney, strengthen bones and muscles, blacken hair, make people have children for a long time, and make people fit and prolong life." Side effects of Polygonum multiflorum Thunb: Polygonum multiflorum Thunb generally has no side effects, but it can slip the intestine and cause mild diarrhea, so people with loose stools should not take it.