Urticaria is a disease with complicated etiology. If you just ask what medicine to take, you may need to consider it from several aspects. The first one is to find out the cause of urticaria, especially chronic urticaria, and stop contacting these special reasons and avoid contacting some reasons. Secondly, the general choice of drug therapy is antihistamines. There are two kinds of antihistamines. The first kind is the antagonist of H1 receptor. Generally, we often know some chlorpheniramine, loratadine, cetirizine, ebastine and fexofenadine hydrochloride. This kind of antihistamines has a clear effect and a good antipruritic effect. Antagonists of H2 receptor include famotidine, ranitidine and cimetidine, which can generally be considered to be used alone or in combination with one or two drugs of H1 receptor, or in combination with H1 and H2 receptor. Secondly, drugs that inhibit mast cell degranulation, such as ketotifen, and second-line drugs, such as glucocorticoid and immunosuppressants, can also be considered. Of course, it is recommended that you take Chinese medicine to treat urticaria, especially chronic urticaria. You need to go to the hospital for treatment based on syndrome differentiation and choose appropriate prescriptions. For the above-mentioned drugs for urticaria, you must follow the doctor's instructions, you can't choose the specific dosage by yourself, and there are selected varieties. You must take them according to the doctor's advice.