According to the map, the route ① goes from Guangdong Province to Hunan Province and finally to Shandong Province, so A is correct;

Route 2 starts from Yunnan Province, passes through Sichuan Province and reaches Inner Mongolia Autonomous Region, so B's statement is correct;

③ The route starts from Xizang Autonomous Region, passes through Qinghai Province, and finally reaches Shanxi Province, which is located in the northern region, so C is wrong.

Route 4 is located in Xinjiang Uygur Autonomous Region, where fruits and vegetables are particularly sweet and there are delicious cumin kebabs, so D is correct.

So choose: C.