Hirschsprung's disease is a common congenital gastrointestinal malformation in children. The incidence rate was1/5000 ~1/2000, which was significantly higher in males than in females, with the ratio of 3:1~ 4:1. The disease has a familial predisposition, and its genetic mode may be polygenic inheritance.

This question aims at the knowledge point of "basic knowledge-etiology and pathogenesis of Hirschsprung's disease"