Oocyte freezing technology

Women need to take ovulation-promoting drugs before taking eggs, so that multiple follicles develop ahead of time, and multiple eggs are discharged by puncture technology, so that multiple eggs can be obtained at one time. [2]?

Oocytes were cryopreserved in liquid nitrogen at-196℃ for many years. No matter how many years, as long as the technology is excellent, as long as it is thawed successfully, it will move like a fresh egg, because all metabolism and molecular movement inside the egg will stop in a low-temperature liquid nitrogen environment. However, the international clinical practice is to preserve oocytes in cryopreservation for 5 years. [2]?

Egg freezing technology is indeed developing step by step. It was slow freezing at first, but now it can be frozen soon. Rapid freezing, also called vitrification freezing, can make the protective solution drop to-196℃ in a short time and become glassy, which can better prevent egg cells from being damaged by ice crystals during freezing. However, compared with mature sperm freezing and embryo freezing technology, egg freezing technology is still immature and far from maturity. [2]?

According to relevant data, since the birth of the first baby with slow oocytes cryopreservation in the world in 1986, there are only over 200 babies born by egg cryopreservation technology in the world, and less than 20 in China. Wang, director of the Reproductive Medicine Center of the Third Affiliated Hospital of Zhengzhou University, told the reporter that the cryopreservation technology of oocytes developed by domestic hospitals is based on medical means of certain diseases, mainly used to solve the problem of infertility, and it is a last resort. For the long-term fertility of healthy women, cryopreservation of oocytes has not been widely carried out internationally. [2]?

The significance of cryopreservation of oocytes and the establishment of an egg bank is to enable women who don't want children for the time being to preserve young, healthy and fertile eggs, so as to keep their fertility in the strongest period. However, if we want to provide perfect maternity insurance for women, simply freezing eggs is not enough, especially for premature ovarian failure and young tumor patients. Experts pointed out that the most ideal way is to take out ovarian tissue and freeze it before chemotherapy, and then transplant or culture it in vitro after the condition is relieved. [2]?

main problem

Drugs stimulate egg retrieval, which is harmful to women's health.

Women can only produce one mature egg every month from menarche, and the highest quality egg is between 25 and 30 years old. After the age of 30, the quality of eggs will decrease year by year. Because of this, some modern women hope to preserve high-quality eggs by freezing for later use. According to the reporter's inquiry, there are still many women who consult online to store high-quality eggs in advance. [2]?

Taking eggs is not a simple matter, far less simple than taking sperm. Men don't need to take medicine to get sperm, and they may get thousands of sperm at a time, which is harmless to health. However, women only have more than 400 eggs in their lifetime, and their eggs have poor viability and are not easy to preserve. So no matter what the purpose is, in order to ensure that there are enough eggs available, it is impossible to save only one or two eggs, and it is necessary to save a dozen or twenty eggs. [2]?

However, ovulation drugs are easy to over-stimulate the ovaries, causing women to suffer from ovarian hyperstimulation syndrome, causing ascites, swelling, irregular menstruation, premature ovarian failure and so on. Taking eggs requires puncture, which is easy to be infected and may also damage ovarian function and endanger women's health. [2]?

Healthy women may lose more by taking eggs and freezing them.

Frozen embryos and frozen sperm are mature, but even so, it is not recommended to freeze sperm and embryos for too long in clinic. Like frozen sperm, it is generally recommended not to exceed half a year, and the embryo freezing period should not exceed two years. 20 13, cryopreserved oocytes, a baby born in Shanghai ruijin hospital, frozen for 4 months. And those women who want to freeze high-quality eggs in advance hope that the eggs can be frozen for more than five years, not more years. [2]?

At present, egg freezing technology is not mature, eggs are very sensitive to temperature and cryoprotectants, freezing may destroy the fine structure of eggs, and the cell structure of eggs may be destroyed during thawing, and the recovery rate of eggs after thawing is not high. So, how long can sensitive and fragile eggs be frozen?

The cryopreservation technology of eggs is immature. Frozen storage for many years, the quality is uncertain, and women taking eggs in advance will cause a series of health hazards. In this way, I'm afraid it's not worth the loss to take so many risks just for a good egg.