Description of the problem:

I just got over a cold, but I keep coughing with thick phlegm, and I don't know what happened to the medicine my mom bought me, but there's no instruction manual, so can you tell me what Meleumycin Tablets are supposed to do?

Ans:

Drug Name Meleumycin Tablets

English Name Meleumycin Tablets

Drug Alias

Properties

The product is sugar-coated tablets, white or off-white color after removing the sugar coating.

Pharmacological effects

This product is a 16-member ring macrolide antibiotic, antibacterial spectrum is broad, effective against most gram-positive bacteria, some negative bacteria and some atypical pathogens. Among the gram-positive bacteria, it is highly sensitive to Streptococcus coagulans, Streptococcus pyogenes D-58 and Streptococcus pneumoniae, and is also effective against Staphylococcus aureus, Staphylococcus epidermidis, S. pneumoniae, Streptococcus haemolyticus, Corynebacterium diphtheriae and Clostridium difficile. Among Gram-negative bacteria, Dictyostelium gonorrhoeae and Dictyostelium meningitidis are moderately sensitive to the product. Among atypical pathogenic bacteria, this product has good bacteriostatic effect on Mycoplasma pneumoniae, Chlamydia, Legionella. The mechanism of action of this product is mainly to bind to the bacterial 50s ribosomal subunit and inhibit bacterial protein synthesis by blocking transpeptidation and mRNA translocation. This product is a non-induced resistance antibiotic that does not induce staphylococcal resistance to macrolide antibiotics.

Pharmacokinetics

This product on the digestive tract *** less than erythromycin, resistance to gastric acid damage than erythromycin strong, 2 hours after oral administration can reach the peak concentration of blood. This product belongs to the high fat solubility of the weak alkaline drug, has a good tissue transit. After absorption, it is widely distributed, especially in the liver, kidney, lung and other tissues with high concentration. It can be several times higher than the blood concentration. The concentration in pleural and abdominal water, pus, sputum, subcutaneous tissue and bile is also high, the product is not easy to pass the blood-brain barrier, so the concentration in the cerebrospinal fluid is low. The product is mainly metabolized in the liver, excreted from bile via the feces, and to a lesser extent in the urine (24-hour excretion is approximately 2% to 3% of the administered dose). The t1/2 for oral administration of this product is 2.4 hours.

Indications

This product is an antibiotic. It can be used for the treatment of otorhinolaryngological infections, stomatological infections, respiratory infections, skin and soft tissue infections caused by sensitive gram-positive bacteria such as Streptococcus pyogenes, Streptococcus haemolyticus, S. pneumoniae and Staphylococcus staphylococcus, including pharyngitis, tonsillitis, scarlet fever, dengue, lobar pneumonia, and so on, which are caused by them. Penicillin G-resistant and allergic to penicillin can be used. It can also be used to treat infections caused by sensitive atypical pathogens such as Mycoplasma, Chlamydia and Legionella, such as nongonorrheal urethritis, prostatitis and Legionnaires' disease.

Dosage

Oral: Adults 8~12 tablets per day, divided into 3~4 times; pediatrics 20mg per kilogram of body weight per day, divided into 3~4 times. It is suitable to increase or decrease with age and symptoms.

Adverse reactions

1, gastrointestinal reactions: less and lighter than erythromycin and other 14-membered ring macrolide antibiotics, nausea, vomiting, abdominal discomfort, diarrhea, and other reactions after oral administration of this product.

2, allergic reactions: rare urticaria, drug fever, eosinophilia and so on.

3, liver adverse reactions: less than erythromycin and light, only individual patients occasionally see transaminase elevation.

Contraindications

Allergy to macrolide antibiotics is prohibited.

Precautions

1. Use with caution in pregnant and lactating women.

2, this product is a fast-acting bacteriostatic agent, should not be combined with β-lactam reproductive bactericides to avoid antagonism.

3, this product should not be used in combination with chloramphenicol and lincomycin antibiotics, so as not to reduce the efficacy.

4, this product is a 16-member ring macrolide, does not form a metabolic complex with cytochrome P450, so there is no significant interaction with theophylline, amidamizine, methylprednisolone, etc., and generally do not occur erythromycin and other potential adverse reactions in the combined use of drugs.

5, this product and other macrolide antibiotics have a closer cross resistance.

Overdose

Overdose can increase the incidence of the above adverse reactions or drug poisoning.

Specifications 0.1g (100,000 units)