Functions and Indications

Jaundice; dysentery; sand drench; leucorrhea; edema; boils and swelling; bruises; poisonous snake bites. Clearing heat and inducing dampness, detoxifying and eliminating swelling. Used for hepatitis, cholecystitis, dysentery, nephritis edema, urinary tract infection, urinary stones, tonsillitis, bruises.

Use and Dosage

Internally: decoction, 6-15g, fresh 30-60g. Externally: appropriate amount, pounded compress.

Taste and odor

Slightly bitter, sweet, freezing. Into the water, wind tower.

Accessory prescription

1, the treatment of "拢牛", "拢蒙沙嘿 "Horseshoe gold 15g, swine sign grass 10g, plantain 15g, vervain root 15g. decoction.

2, the treatment of "拢案答勒" horseshoe gold 30g, 15g of fenugreek tea, 15g of cassia root, 15g of white fescue root, 20g of bluegrass root. decoction.

3, the treatment of "the together harmful buried冒巴" horseshoe gold 20g, gourd tip 15g, black sugar cane bud eyes 20g, calamus 10g. decoction.

4, the treatment of "together pest line" horseshoe gold 30g. decoction, add a little salt to take.

5, the treatment of "拢沙龙接火", "拢沙龙接喉改板,哦勒", "拢沙龙答接泵亮", "说凤令兰 "Horseshoe gold 15g, pounded, outside the water to take.

Drug contraindications

"Compendium of Gleanings": avoid salt.

Pharmacological effects

1, hepatoprotective and enzyme-lowering effects

Pharmacological experimental studies show that horseshoe gold extract has a certain therapeutic and protective effect on carbon tetrachloride (CCl4)-induced acute hepatic injury in animals, and it can significantly reduce the elevated serum transaminases of the mice induced by hepatic injury in 1 week and 3 weeks; it can make the liver reduce the pathological changes, and it can also make the liver injury invert the The white globe ratio was elevated; experiments with the fresh herb juice of horsetail gold showed that it dose-dependently reduced the serum alanine aminotransferase (ALT), the content of malondialdehyde (MDA) in serum and liver tissues of mice with CCl4 toxicity, significantly increased the level of superoxide dismutase (SOD), and markedly attenuated the degeneration and necrosis of hepatocytes, so that it had a significant protective effect on acute liver injury caused by CCl4 and. ALT is released by massive lipolysis of mitochondrial membrane lipids in damaged hepatocytes. The drug can reduce cell membrane permeability and inhibit the release of intracellular enzymes, thus improving liver injury and promoting the recovery of liver function.The content of MDA reflects the degree of tissue peroxidation, and SOD is an antioxidant enzyme in the organism, which can scavenge free radicals, and prevent free radicals from damaging the cell structure. The fresh juice of horseshoe gold can reduce the MDA content, increase the activity of SOD, reduce lipid peroxidation in the liver and achieve the effect of liver protection.

It can significantly reduce the serum aminotransferase and triglycerides in the liver of mice with liver injury caused by D-galactosamine (D-Glan), thioacetamide (TAA) and isothiocyanate-1-naphthyl ester (ANIT) and alleviate the pathological changes of liver tissues; it can reduce the serum gammaglutaminase in the mice with liver injury, and reduce the elevated serum total aminotransferase in the mice with bilirubic jaundice caused by the juice of horseshoeskin. It can reduce the elevated serum total bilirubin (Tbil) and serum aminotransferases (ALT and AST) in mice with experimental jaundice, improve experimental jaundice-type liver injury, and promote the recovery of liver function so that the bilirubin can be normally excreted, thus playing the role of protecting the liver and eliminating the yellowish color; it can also significantly reduce the content of triglycerides (TG) in the liver tissues. In the test of anti-hepatitis B virus, the maximum non-toxic concentration of compound (2R,3R)-2,3-dihydroxy-2-methyl-γ-butyrolactone was 0.4 μmol/ml, the inhibition rate of HBsAg was 22.4%, and the inhibition rate of HBeAg was 19.6%, which had certain inhibition of hepatitis B virus. The active components of the hepatoprotective effect of Horseshoe Gold and its specific cellular molecular biological mechanism need to be further investigated.

2. Analgesic effect

The mice were stimulated by twisting method, hot plate method, and electric stabbing method, and were administered with different doses of horseshoe gold extract to determine the pain threshold of the mice. The results showed that the horseshoe gold extract had a good analgesic effect.

3, anti-inflammatory effect

Small doses of horseshoe gold extract on acetic acid caused by the increase in capillary permeability has a significant inhibitory effect; inhibition of carrageenan caused by the inflammatory swelling of the rat toe. Both horseshoe gold extract and its petroleum ether extract could significantly inhibit xylene-induced acute inflammatory edema of mouse auricle, but the anti-inflammatory effect of the petroleum ether extract of horseshoe gold did not have a significant dose-dependent relationship, and the medium dose always had better pharmacological activity for different inflammation models.

4, antibacterial effect

Microbial tests show that horseshoe gold extracts of Staphylococcus aureus, hemolytic streptococcus B and other Gram-positive pathogenic cocci have a strong antibacterial effect; and on Escherichia coli, typhoid fever, Escherichia contorta, aerobic bacilli and other Gram-negative bacilli have a weaker effect, mainly inhibitory effect. It is ineffective against Fusarium dysenteriae.

5, antipyretic and choleretic effect

The large dose of horseshoe gold extract (32.5g/kg) can significantly reduce peptone-induced febrile body temperature in rats, and the duration of a longer period of time, there is a good antipyretic effect. Bile flow was significantly increased within 120 minutes by injecting a small dose of horseshoe gold extract (8.2g/kg) into the duodenum of rats, indicating that the drug has a strong choleretic effect. '

6, enhance the role of immunity

A small dose of horseshoe gold can significantly increase the weight of the animal immune organs thymus and spleen, enhance the phagocytosis of mononuclear macrophages, and increase the level of serum hemolysin, indicating that the drug has the role of promoting cellular and humoral immunity.

7, anti-cancer effect

Higher Se content in horseshoe gold determined by HG-ICP-AES, elemental Se has a high antioxidant activity, 50-500 times that of vitamin E, which can remove free radicals in the body, prevent organ aging and lesions, delay aging, enhance the human immune system, and resist the toxic effects of toxic heavy metals. Research has proved that element Se can inhibit the growth of cancer cells and their DNA, RNA and protein synthesis, inhibit the transcription of oncogenes, interfere with the metabolic process of carcinogenic substances in the human body, thus effectively fighting cancer. Horseshoe gold has the advantages of long life, long green period, beautiful form, easy to reproduce, easy to manage, shade, high temperature and so on, it is a kind of excellent lawn grass and ground cover greening material, which can be called "green carpet", it is suitable for the parks, institutions, courtyard greening, etc. Cultivation of ornamental, but also can be used for ditch slopes, embankment slopes, roadsides, etc. Soil-solidifying materials.

The horseshoe gold leaf color green, low plant, leaf blade dense, beautiful, light trampling resistance, vitality, strong resistance, adaptability, low requirements for growth conditions, no pruning. Horseshoe gold has both ornamental value and the role of soil stabilization and slope protection, greening and purifying the environment. It has been widely used in the northern subtropical areas of southern China as an excellent ground cover plant.