1. allergic reaction: mild skin allergic symptoms, such as skin itching, skin flushing, miliary papules all over the body, or round irregular patches; In severe cases, anaphylactic shock occurs, manifested as fever, dizziness, nausea, chest tightness, palpitation, and even coma and unconsciousness.

2. Gastrointestinal reaction: Vomiting, diarrhea and gastrointestinal bleeding can be seen.

3. Bleeding reactions: mainly thrombocytopenia, nosebleeds, gingival bleeding, skin bleeding, oral ulcers, etc.

4. Urinary system reaction: frequent micturition, dysuria, hematuria, backache, and severe cases can cause liver, kidney, spleen and myocardial damage.

The main component of poisoning caused by Niuhuang Jiedu tablets is realgar. Arsenic disulfide in realgar decomposes when exposed to heat and becomes highly toxic arsenic trioxide (the main component of arsenic), causing arsenic poisoning. When adults take Niuhuang Jiedu tablets, the number of small tablets should not exceed 9 and the number of large tablets should not exceed 6 per day. Excessive or long-term use should be avoided.