Hypertension, hyperlipidemia, atherosclerosis, coronary heart disease, etc. , are often interrelated. Hypertension can promote the release of vasoactive amines in large quantities, cause damage to vascular endothelial cells, increase the intercellular space, make lipoprotein in blood more easily penetrate the vascular wall, and aggravate the progress of hyperlipidemia. Hyperlipidemia will lead to thickening of the intima of arteries, increased vascular resistance, and eventually lead to an increase in blood pressure.

With the promotion of hypertension and hyperlipidemia, atherosclerosis and coronary atherosclerosis (coronary heart disease) follow. Therefore, we have been looking for drugs that can take care of the three, with Shubao Capsule and Xinkeshu Capsule as the representatives, which can take care of hypertension, hyperlipidemia and coronary heart disease, and treat both the symptoms and root causes.

Xinshubao, a national protected variety of traditional Chinese medicine, consists of hawthorn, salvia miltiorrhiza, acanthopanax senticosus, white peony root and turmeric. Has the effects of promoting blood circulation, removing blood stasis, benefiting qi and relieving pain. It is suitable for coronary heart disease, chest distress, angina pectoris, hypertension, hyperlipidemia and arteriosclerosis caused by qi deficiency and blood stasis.

Hawthorn has the effects of promoting digestion, promoting blood circulation and removing blood stasis. Salvia miltiorrhiza for promoting blood circulation and removing blood stasis, supplemented with acanthopanax senticosus for invigorating qi and nourishing blood, can improve the curative effect; Radix Paeoniae Alba and Radix Curcumae can nourish liver and kidney, and benefit essence and blood. Modern pharmacological research shows that many acidic components in hawthorn have strong hypolipidemic activity; Salvia miltiorrhiza extract has the effects of repairing vascular endothelial function and improving immunity. The glycosides in Radix Paeoniae Alba can also effectively reduce the blood lipid content.

Clinical research shows that Xinshubao capsule has the functions of reducing blood lipid and preventing atherosclerosis, preventing lipid accumulation in intima and subcellular of arterial wall, and preventing coronary atherosclerosis and thrombosis. It has good curative effect and safety on angina pectoris of coronary heart disease with qi deficiency and blood stasis. Has the effects of dilating coronary artery, inhibiting platelet aggregation, resisting thrombosis, improving microcirculation, and improving myocardial ischemia. So as to obviously improve the symptoms of chest tightness, chest pain, palpitation, shortness of breath and the like of patients with coronary heart disease and relieve angina pectoris.

Endothelin-1 is a potent vasoconstrictor, which can stimulate sustained vasoconstriction, promote platelet aggregation and thrombosis, and aggravate the risk of cardiovascular events. Angiotensin Ⅱ is a vasoconstrictive peptide, which is involved in regulating blood pressure. Homocysteine is an independent risk factor for cardiovascular and cerebrovascular events, which can directly damage vascular endothelial cells and promote the formation of atherosclerotic plaques.

Clinical research shows that the levels of plasma endothelin-1, angiotensin ⅱ and homocysteine in patients treated with Xinshubao capsule combined with valsartan and other conventional antihypertensive drugs are lower than those in the control group, and the 24-hour systolic blood pressure, diastolic blood pressure, systolic blood pressure and diastolic blood pressure fluctuate lower than those in the control group. It shows that the combination of the two methods can improve the vascular endothelial function of patients with hypertension, control the blood pressure variability of patients with hypertension, and have positive significance for lowering blood pressure, alleviating the damage of vascular endothelial function and delaying the development of diseases.

Xinkeshu Capsule is composed of Fructus Crataegi, Radix Salviae Miltiorrhizae, Radix Puerariae, Radix Notoginseng and Radix Aucklandiae. It has the effects of promoting blood circulation to remove blood stasis, promoting circulation of qi and relieving pain, and is suitable for coronary heart disease, chest distress, angina pectoris, dizziness, headache, stiff neck, arrhythmia, hypertension and hyperlipidemia of qi stagnation and blood stasis type.

Modern pharmacological research shows that many effects of the drug on cardiovascular system are mainly related to the following aspects: Salvia miltiorrhiza contains tanshinone and danshensu, which can scavenge free radicals in the body and inhibit lipid peroxidation, thus protecting vascular endothelial cells. At the same time, it can promote myocardial contraction, improve cardiac function and reduce myocardial oxygen consumption.

At the same time, it can inhibit coagulation function, affect various coagulation factors, reduce blood viscosity, improve hemorheology, adjust cell electrophoresis rate and hematocrit, thus improving blood circulation. Panax notoginseng can enhance the activity of fibrinolytic system, improve hemodynamics and help lower blood pressure. Crataegus pinnatifida, Radix Puerariae and Radix Aucklandiae have the effects of lowering blood lipid and blood pressure.

Clinical research shows that patients treated with routine antihypertensive drugs such as Xinkeshu capsule and irbesartan have better blood pressure drop, left ventricular hypertrophy index and left ventricular function recovery than the control group. For hypertensive patients with left ventricular hypertrophy and myocardial ischemia, Xinkeshu capsule combined with irbesartan tablets can significantly lower blood pressure, delay myocardial remodeling and contribute to the recovery of left ventricular function.

Similarly, in patients with hypertension complicated with hyperlipidemia, the corresponding blood lipid indexes of patients were further improved after combined treatment with Xinkeshu capsule on the basis of routine treatment. The results of the study confirmed that the combined treatment scheme has a good effect of reducing blood lipid, and can also reduce the inflammatory reaction of patients, effectively repair the vascular endothelial injury of patients with hypertension complicated with hyperlipidemia, and reduce blood pressure and blood lipid.

In a word, Xinshubao Capsule and Xinkeshu Capsule can reduce blood viscosity, inhibit platelet aggregation, increase blood flow of tissues and organs, promote fibrinolytic enzyme activity, improve blood circulation and enhance left ventricular function through various ways and mechanisms. It can not only effectively improve the symptoms related to coronary heart disease and angina pectoris, but also further reduce blood pressure, blood lipid, anti-atherosclerosis and protect cardiovascular system.