The main ingredient of coffee is caffeine. Drinking too much coffee will stimulate the peristalsis of the stomach and the secretion of gastric acid, causing gastrointestinal spasm. It can also lead to chronic gastritis. At high dose, caffeine can cause tachycardia, and sensitive person may have arrhythmia such as premature contraction. Drinking coffee for a long time can increase the blood cholesterol concentration, but this is not caused by caffeine, but related to other components contained in coffee.
Drink coffee in moderation.