After 18 years old, there is no sign of neurofibromatosis, and neurofibromatosis can be basically ruled out. Neurofibromatosis can be divided into NF 1 type and NF2 type, among which NF 1 type is more common in childhood, and its clinical symptoms include skin coffee spots, multiple neurofibromas and iris Leigh's nodules. NF2 is easy to be diagnosed, and it is characterized by bilateral acoustic neuromas and other central nervous system tumors. However, the specific diagnosis needs to be combined with the doctor's evaluation and further examination.