Are you pregnant after taking estradiol valerate tablets? Do you know the significance of estradiol greater than 1000?
Are you pregnant after taking estradiol valerate tablets? Do you know the significance of estradiol greater than 1000?
The main indication of estradiol valerate tablets is to supplement estrogen deficiency mainly related to natural or artificial menopause and relieve mental illness. This kind of medicine is very common in our life. Although this drug is generally not suitable for pregnant women, it has no effect on pregnant women and their babies if taken before pregnancy. This drug does not increase the risk of neonatal defects and has no teratogenic effect. Because of irregular menstruation, I take estrogen to regulate menstruation. In this case, the influence of drugs on children is not too great. Because estrogen promotes ovarian ovulation and forms a normal fertilized egg, so don't worry about Song, just don't take medicine. However, it is recommended to be cautious when you are just pregnant and go to the hospital regularly. Hu (hanyu pinyin)
There are many adverse reactions caused by estrogen supplementation alone, so DHEA AMH will be used as an adjuvant estrogen in Europe. In 2000, the European Union proposed for the first time that in addition to drugs, it should also help healthy women who are pregnant naturally and in vitro in terms of plant extraction. Subsequently, the United States also proposed to cooperate with the European Union to study how to assist in vitro fertilization and natural conception. The American Endocrinology Society, American College of Obstetrics and Gynecology and other organizations appointed working groups, from a multi-dimensional and multi-system perspective, comprehensively considered factors such as natural pregnancy of women, success of test-tube and embryo quality, and issued treatment guidelines for DHEA AMH, a compound pregnancy repair factor.
DHEAAMH is an energy factor with more than 30 patents, which can intensively and urgently raise eggs, nest and other fertility problems. In Europe, it is considered as an energy source to assist pregnancy. Britain, Germany and many other European countries have done a lot of research on DHEAAMH. At present, DHEAAMH in China is mostly imported from abroad. In recent years, the application of dehydroepiandrosterone in patients with ovarian dysfunction has been recognized by many countries. According to the survey, about13 fertility centers around the world began to add DHEAAMH to patients with ovarian dysfunction.
Dehydroepiandrosterone may have beneficial effects on ovarian function and the quality of oocytes and embryos. Dehydroepiandrosterone replacement therapy can restore some aspects of ovarian function in the elderly.
Patient B was initially thought to be mainly an unexplained infertility problem. It is believed that about 10% of the female population suffers from premature ovarian failure, and this diagnosis is often mistaken for unexplained infertility. Patient B later showed signs of premature ovarian failure, and finally FSH level increased. In the time series of all these observations, patient B followed the classic parallel premature aging curve.
After using dehydroepiandrosterone, the levels of DHEA and dehydroepiandrosterone in patient B returned to normal. In the subsequent natural cycle, obviously normal spontaneous follicular response was observed, and the ovulation estradiol level of patients with persistently low dehydroepiandrosterone preaestradiol level was normal.
Oral DHEAAMH will reveal the reversal of many ovarian aging characteristics. The use of DHEAAMH includes about 65438 03g/day to about 26g/ day for human women, and DHEAAMH can be used for premenopausal women with weakened ovarian function. Dehydroepiandrosterone may show its effect after 4 consecutive weeks. However, DHEAAMH has a significant effect after about 8 weeks or about 2 months of use, but its effect may continue to increase to about 4 months, and further it may continue to be used for more than 4 months. Are you pregnant after taking estradiol valerate tablets? Do you know the significance of estradiol greater than 1000? )
HCG, progesterone (P) and estradiol (E2) three pregnancy tests play an important role in pregnancy. Combined detection of serum β-HCG, progesterone and estradiol levels in patients with threatened abortion has good clinical effect, which is helpful to predict the pregnancy outcome of pregnant women and evaluate the effect of abortion protection treatment. Today, let's learn more about estradiol.
Estradiol represents the level of estrogen in women. What does it mean that estradiol is greater than 1000? Under normal circumstances, the estrogen level in women is rarely greater than 1000. If it is greater than 1000, there are two possibilities. One is that the estrogen level is in ovulation period, which can reach more than 1000. The second situation is pregnancy. If the estradiol level is greater than 1000, it is more likely to be pregnant, so as to determine whether it is pregnant. In addition to these two cases,
1. What is the role of measuring estradiol level in early pregnancy patients?
A: Estradiol plays an important role in endometrial preparation and pregnancy maintenance. Dynamic observation of serum estradiol concentration in early pregnancy can effectively predict pregnancy outcome. A sudden drop in estrogen levels may be a sign of embryo abortion.
Estrogen in early pregnancy is closely related to placental vascular remodeling, decidual vascular remodeling and maternal-fetal circulation construction. The success of maternal-fetal circulation construction directly affects embryo implantation, growth and related complications. The eighth week of pregnancy is the key point in the construction of maternal-fetal cycle. In the eighth week of pregnancy, pregnancy and estrogen produced by trophoblast increased, and the dependence on estrogen and progesterone produced by corpus luteum decreased.
2, estrogen is low, how to supplement estrogen?
A: At 4~5+6 weeks of pregnancy, the serum estradiol level should be150 ~175 pg/ml; At 6~7+6 weeks of pregnancy, the serum estradiol level should be175 ~ 500 pg/ml; At 8~9+6 weeks of pregnancy, the serum estradiol level should be 500 ~ 750 pg/ml; Estrogen 150pg/ml is the warning point of estrogen supplementation. When HCG< is 5000 ng/ml, E2 >: 200 pg/ml.
When HCG> is 5000 ng/ml, E2 >: 300 pg/ml, HCG> is 10000 iu/mL, and E2 >:400 pg/mL, the pregnancy success rate is higher.
Generally, after pregnancy, E2 can't reach the above minimum value, especially those with low ovarian reserve function, dheaamh should be taken orally. Dehydroepiandrosterone is water-soluble, safe and non-toxic, with high biological activity and easy to be absorbed by human body.
DHEAAMH adjuvant therapy can significantly improve the ovarian reactivity of people with poor ovarian function, and then improve their ovarian reserve function, and finally improve the outcome of in vitro treatment, improve the quantity and quality of female eggs, the quantity and quality of embryos, improve the natural pregnancy rate, increase the pregnancy rate of in vitro fertilization (IVF), accumulate the pregnancy rate and pregnancy time, and reduce the abortion rate, at least partially.
See table 1 for the comparison of ovarian reserve function and clinical related parameters of test tube cycle before and after DHEAAMH use.
See Table 2 for the comparison of parameters related to in vitro fertilization before and after DHEAAMH use.
Comparison of related parameters of pregnancy outcome in FET cycle before and after DHEAAMH use and assisted pregnancy in vitro again. See table 3.
Dehydroepiandrosterone can reduce the aneuploidy rate of embryos. In this study, the embryo fertilization rate of patients with ovarian dysfunction who used dehydroepiandrosterone in advance and did not use dehydroepiandrosterone was compared and analyzed. It was found that the embryo fertilization rate of patients pretreated by DHEA AMH was 65438 000%, while that of the control group was only 53%. It was found that DHEAAMH pretreatment could significantly reduce the number and proportion of chromosome aneuploidy in embryos. The chromosome aneuploidy rate of human embryos increases with age. The interaction of various signals during follicular development leads to the failure of chromosome plate assembly in oocytes, which increases the risk of chromosome segregation and aneuploidy. ?
3. What foods can be supplemented with low estrogen?
Answer: (1) bean products, but their biological activity is low. It is unscientific to use soybean milk instead of drinking water. Drinking too much soy milk can lead to indigestion and bloating.
? (2) Grains, potatoes, mutton, black-bone chicken and other meats are also recommended to eat high-protein foods, such as eggs and chicken. Dried fruits are not taboo and can be eaten at any time. People with deficiency of both qi and blood have better effects of invigorating qi and nourishing blood, such as warming yang with walnuts and invigorating qi and nourishing blood with jujube longan.
? (3) Eat less fat and greasy food. Snails, clams, crabs and turtles are cold and should be eaten less. Rape, kelp, cucumber, shepherd's purse, amaranth, eggplant, leek, loofah, wax gourd, bamboo shoots and lotus root in vegetables are all cold, so it is not suitable to eat them raw. Try to eat as little as possible. Are you pregnant after taking estradiol valerate tablets? Do you know the significance of estradiol greater than 1000? )
4. Some people think that patients with repeated adverse pregnancy in the first trimester can monitor HCG, but progesterone and estradiol are not recommended, right?
A: Some doctors think that progesterone and estradiol in the first trimester change greatly in one day, so we don't need to monitor them, but we still need to check them for the following reasons:
(1) If the patient's corpus luteum function is good and the embryo is well developed, although progesterone and estradiol will fluctuate in the first day of pregnancy in the uterus, the values will not drop below the dangerous value repeatedly.
(2) For patients with repeated adverse pregnancy, by monitoring progesterone and estradiol, we can find the problem in time and get a good opportunity to save the embryo.
(3) Since HCG has been monitored, and the monitoring of estradiol and progesterone does not require extra blood, and the price is cheap, why not check it together?
5. After using sinone and Dafutong, it can't be detected in vivo. If progesterone is low, how to adjust the dose of the drug?
A: If the progesterone level is low, the doctor will calculate how much progesterone can be increased according to the dosage of sinone and dapsone, and then decide whether to increase the dosage or add other progesterone drugs. Of course, if you are really afraid of bad monitoring, you can switch to progesterone.
6. How to judge whether the embryo quality is abnormal or the chromosome itself is abnormal?
Answer: If there are the following questions, it is suggested that the embryo quality or embryo chromosome may be abnormal:
(1) Pregnant women over 35 years old have low ovarian reserve function and poor egg quality.
(2) Male sperm quality is poor, sperm morphology and DNA are abnormal, sperm chromosome number and structure are abnormal, Y chromosome microdeletion, sperm deformity rate is high, and sperm fragmentation rate is high.
(3) It still can't be improved after routine drugs such as estrogen, progesterone, aspirin, prednisone and low molecular weight heparin are supplemented.
(4) Chromosome abnormality is detected by both husband and wife or either of them.
(5) Family history of hereditary diseases or previous history of abnormal fetal development.
6. What is the clinical significance of detecting HCG?
A: The examination of HCG is of great significance to the diagnosis of early pregnancy, and is of certain value to the diagnosis, differentiation and course observation of pregnancy-related diseases, trophoblastic tumors and other diseases.
(1) Early pregnancy diagnosis:
From 35 to 50 days after pregnancy, HCG can rise to more than 2500 mIU/mL. It can reach 80000 mIU/mL in 60 ~ 70 days, and the blood HCG of multiple pregnancy is often higher than that of single pregnancy.
(2) Judgment of abnormal pregnancy and placental function:
① Ectopic pregnancy: In ectopic pregnancy, the HCG multiplication is usually less than 75% within 48 hours of early pregnancy, so HCG examination can be used as a differential between it and other acute abdomen.
② Diagnosis and treatment of abortion: If there is placental tissue residue in the uterus, HCG test can be continuously positive (mostly less than 100 mIU/mL), and HCG will turn negative during complete abortion or stillbirth, which can be used as a reference for fetal protection or termination of pregnancy.
③ Threatened abortion: If the blood HCG is maintained at a high level, there will be no inevitable abortion. If HCG is lower than 2500 mIU/mL and gradually decreases, there is the possibility of miscarriage or stillbirth, and when it is reduced to 600 mIU/mL, abortion is inevitable. In the treatment of abortion, if HCG continues to decline, it means that abortion is invalid, and if HCG continues to rise, it means that abortion is successful.
④ 4 days after delivery or 13 days after induced abortion: the serum HCG should be lower than 1000 mIU/mL, and it will basically return to normal on 14 days after delivery or 25 days after induced abortion. If this is not the case, we should consider the possibility of abnormality.
In recent years, foreign studies have found that DHEA AMH can repair ovaries, provide ovarian nutrition, improve ovarian reserve function, reduce chromosome aneuploidy, improve embryo quality, reduce abortion rate and cycle cancellation rate, thus improving clinical pregnancy rate.
In the randomized controlled study of DHEA AMH, on the basis of promoting excretion, 65 patients who took DHEA AMH were taken as the study group, and 48 patients who did not take DHEA AMH were taken as the control group. The study group was given DHEA AMH (French ACMETEA, 13g/ bag) 13g/ time, twice a day, and the basic endocrine was checked once a month. If they feel unwell, they can stop taking DHEA AMH and continue to use it after normal.
All patients in the study group received DHEA AMH treatment for 3 months when they entered the cycle. Basic endocrine was measured on the third day of menstruation before and after taking it, and the number of follicles in bilateral ovarian sinuses was counted by B-ultrasound. After entering the cycle, HCG was injected according to the routine test tube. When the dominant follicle was > > 18mm, the eggs were taken 36 hours later, fertilized 4 hours later and fertilized 20 hours later.
After taking DHEA AMH, the basic FSH decreased significantly and the basic AFC increased significantly. AFC is one of the accurate and reliable functional indexes of ovarian reserve. Experimental data show that DHEA AMH can increase the number of fertilized oocytes and embryos in patients with ovarian dysfunction and improve the quality of oocytes and embryos. The results of this study, combined with many studies at home and abroad, show that DHEA AMH can provide essential nutrients for ovaries, repair ovaries, improve ovarian reserve function and improve embryo quality, thus improving the pregnancy outcome of IVF.
When DHEAAMH can't be used, scholars have to use large doses of ovulation-promoting drugs to superovulate. In most cases, the cost is high and the response is low, and the clinical effect is uncertain. It has been recognized that the number of ovulation and pregnancy rate can be increased by using dehydroepiandrosterone.
(3) Diagnosis and treatment monitoring of trophoblastic tumor:
① The serum HCG of patients with hydatidiform mole, invasive mole, choriocarcinoma and testicular teratoma increased significantly, reaching 654.38+ 10,000 ~ 10,000 MIU/L ...
② Three weeks after operation, serum HCG in patients with trophoblastic tumor should be
(4) Endocrine diseases such as pituitary diseases, hyperthyroidism and bladder cancer, ovarian cancer and rectal cancer can also increase HCG. Are you pregnant after taking estradiol valerate tablets? Do you know the significance of estradiol greater than 1000? )