Atypical classical swine fever does not have the typical symptoms and pathological autopsy changes described in textbooks and maps, which makes it difficult to diagnose. Moreover, due to the longer course of disease, there will be secondary bacterial infections (such as secondary porcine pneumonitis, piglet paratyphoid, Actinobacillus pleuropneumoniae and Haemophilus parasuis), and the changes of bacterial diseases cover up the truth of the primary swine fever, resulting in difficulties in diagnosis and medication. The diagnosis of classical swine fever requires fluorescent antibody detection and enzyme-linked immunosorbent assay, but it can't be done in pig farms and pig farmers. Through several years of clinical practice, the following experiences are summarized for reference: those who meet the following four conditions can be suspected of being infected with classical swine fever (1) with persistent high fever (missed fever) above 41-42℃ and purulent canthus. (2) Continuous use of antibiotics for three days is ineffective. (3) Cyanosis occurred in abdomen, ear tip, tail and nose, and paralysis of hindquarters occurred in the older patients. (4) The inoculation dose, inoculation time or the vaccine itself were found out. Treatment measures: (1) classical swine fever serum injection is carried out by serum injection, and the classical swine fever vaccine is re-inoculated 3-5 days after the symptoms disappear. (2) The dose of emergency inoculation of classical swine fever vaccine is15-25, which can be selected according to the weight of sick pigs and the length of disease course. At the same time, with the injection of immune enhancers. After 24 hours of vaccination, you can prescribe the right medicine according to the clinical symptoms, so you don't have to stick to it. Through more than three years' practice, thousands of cases have been treated clinically, and the results are as follows: the cure rate can reach 85% within 0-3 days of onset. 4-7 days after onset, the cure rate can reach 70%. The cure rate can reach 50% after 8 days of onset. The therapeutic effect of atypical swine fever mainly lies in early diagnosis and treatment, and the effect is better when there is no secondary infection.