Zuo Zongtang’s 1 great-grandson Zuo Jingjian is a famous surgical expert and one of the “four knives” of Chinese surgery in the 1960s. His son Zuo Huancong is a surgical expert. In 1994, Zhang Xiaoci went to Beijing to seek medical treatment, and it was Zuo Huancong who performed the surgery on him. Zuo Jingjian's eldest daughter Zuo Huanchen is also a medical student and is an expert in imaging medicine and cardiovascular disease.

Another great-grandson Zuo Jingyi is an academician of the Chinese Academy of Engineering, a professor of the Department of Applied Chemistry of Beijing University of Chemical Technology, and the founder and founder of corrosion and protection science.

Among the descendants of the Zuo family, there is also Zuo Jingquan, a Chinese sinologist living in France, who has made great achievements in Dunhuang studies.