Nausea, vomiting, facial flushing, and dizziness are dose-related and are more common with intravenous than with intramuscular or subcutaneous administration. Polyuria and chills usually cease spontaneously, and only in isolated cases is it necessary to temporarily reduce the dose of the drug. Adverse reactions are listed in order of incidence (Table 1), with incidence defined as follows: very common (≥1/10); common (≥1/100, Table 1