Besniers first described lymph node sarcoidosis 1889. Lymph nodes, spleen, lung, skin, eyes, muscles, bones and joints, meninges, brain, spine, endocrine glands, reproductive organs, breast, kidney, digestive tract, liver and heart can all occur. Lesions can be confined to lymph nodes or skin. According to the 7th International Conference on Sarcoidosis and Other Granulomatosis, the disease is considered as a multi-system granulomatous disease with unknown etiology. This often happens to young people. It is more common in bilateral hilar lymph nodes, lungs and eyelids.

Lymph node sarcoidosis is common in North America and Scandinavia, but it is also found all over the world. The reasons for it were not known It may be related to pine pollen. Injecting pine pollen into human guinea pigs can cause epidermoid cell granuloma. In Britain, people think that most sarcoidosis is tuberculous. It may also be an abnormal immune response caused by a variety of reasons, including mold, non-infectious antigen factors, accidental poisoning and so on.

Sarcoidosis is a systemic granulomatous disease, which is more common in skin and lymph nodes and shows localized damage. Other tissues and organs can also cause diseases such as bones, eyes, hands, lungs, liver, spleen and cheeks. The disease has almost no double and withered membranes, serosa and adrenal glands. The etiology is still unclear, and its histological morphology is quite similar to that of tuberculosis nodules under light microscope. The difference between them lies in sarcoidosis nodules. There is no dry and cool necrotic area in the center of the structure. There are fewer lymphocytes in the visual field around nodules, and there are more tips around some nodules. There are multinucleated giant cells between epithelioid cells, which are similar to multinucleated foreign body giant cells. There are often two forms of inclusion bodies in the cytoplasm: one is stellate body, and the other is Shoman corpuscle (spherical layered calcification). If there is a transparent region in the multinucleated giant fetus, there is a corpuscle with radioactive microsomes. This kind of corpuscle is named star corpuscle, and its formation may be related to the deposition of protein and lipids in cytoplasm. Shaernan corpuscle is considered to be a kind of Berylline-like corpuscle, which is formed by calcareous protein mixture surrounded by calcite crystals. These two are not unique features of sarcoidosis. For example, astrocytes can be seen in the multinucleated giant cells of tuberculosis nodules, while Shore bodies can be seen in the giant cells of granulomatous foreign bodies affected by Shen Chun's disease. The reported damage of nodule A can last for months or years, and the structure of nodule tends to fibrosis and disappear. It is replaced by fibrous tissue and often undergoes vitreous degeneration. Tissue sections of early fibrosis. Silver permeation staining showed that silver fibers were formed in the oral cavity.