High lysine may be hyperlysinemia, which usually does not cause health problems, in rare cases, people with hyperlysinemia may show intellectual and behavioral disorders. This is reflected in symptoms such as developmental delays, epilepsy, periodic vomiting, cerebral palsy, lethargy, diarrhea***济失调与身材短小.

Hyperlysinemia is a rare inherited amino acid metabolism disorder that can only be diagnosed clinically using inexpensive techniques such as tandem mass spectrometry.

But most patients experience misdiagnosis, and the age of diagnosis tends to be in the 5- to 10-year-old range. Hyperlysinemia can be categorized as type I or type II. Typically, type I patients have few clinical symptoms, just high blood lysine concentrations, while type II patients have elevated lysine concentrations along with increased yeast concentrations, and show severe neurological damage and developmental delays, with most dying before adulthood.

Extended information:

After decades of research, scientists have finally figured out the genes responsible for hyperlysinemia, and have a clearer understanding of how the lysine pathway works in the body's main degradation pathway, the yeast pathway. -the yeast pathway. However, the pathogenesis of hyperlysinemia is "confusing".

To this end, the laboratories of Chonglin Yang at Yunnan University/Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Weixiang Guo at the Institute of Genetics and Development, using classical model organisms, such as the nematode Ctenopharyngodon idellus, and mice, have discovered that lysine metabolites, such as yeast, accumulate to disrupt mitochondrial homeostasis and affect development, thus elucidating the pathogenesis of hyperlysinemia in human beings.

Baidu Encyclopedia - Hyperlysinemia

Science.com - Mitochondrial Instability Causes Hyperlysinemia