Commonly used western medications for the treatment of breast hyperplasia include hormonal, iodine preparations and other symptomatic medications. Traditional hormonal preparations mainly use androgens to counteract estrogen, such as oral methyltestosterone in the 10 days before menstruation, once a day, 5-15mg each time, stop before menstruation, the total amount of medication per cycle does not exceed 100mg; or intramuscular injections of testosterone propionate for 3-4 days, 25mg per day.Application of androgenic hormone therapy may have some side effects, such as some masculinized manifestations: hairiness, voice coarsening, acne, etc.; in addition, there may be different degrees of liver damage, dizziness and nausea. Nowadays, people gradually recognize that breast hyperplasia is not simply an increase in estrogen secretion, but due to an imbalance in the ratio of estrogen and progesterone, especially in the luteal phase of the menstrual cycle when the secretion of progesterone is insufficient, and the relative increase in estrogen is caused by this, so it is advocated that progesterone be used for the treatment of this disease to correct the imbalance in the secretion of estrogen and progesterone, and this can be used from 2 weeks before the menstruation, with progesterone taken by mouth for 7 to 8 days, at a daily rate of 5 to 10mg Or intramuscular injection of progesterone 2 times a week, 5mg each time, the total amount of 20 to 40mg. There are also people who advocate the use of small doses of estrogen (1mg) orally during the menstrual period, *** service for 3 weeks, in the subsequent menstrual period and then served, but gradually decreasing, that is, to reduce the amount of drugs and the number of times of drug use, *** use of the drug for 6 menstrual cycles. Taking estrogen can also appear nausea, vomiting, headache and other side effects, some patients can be aggravated, therefore, the application of this method must be under the guidance of a doctor, master the amount and degree.
Because of the breakthrough in the study of hormone receptors, it is recognized that the occurrence of breast hyperplasia and breast tissue local estrogen and progesterone receptor content and sensitivity increase, therefore, began to use hormone receptor antagonists to treat this disease. Such as estrogen receptor antagonist triamcinolone acetonide can competitively compete with estrogen for estrogen receptors, so that estrogen can not play its biological effects, the application of triamcinolone acetonide oral treatment, 2 to 3 times a day, 10mg each time, can achieve a certain degree of efficacy. However, the use of triptans can also produce certain side effects, such as amenorrhea, hot flashes, nausea and so on. In addition, it is also recognized that endocrine disorders caused by breast hyperplasia is not only an imbalance of ovarian endocrine hormones, but also by the hypothalamus, pituitary gland and other endocrine hormones, such as prolactin and other gonadotropins. The use of bromocriptine can inhibit the secretion of prolactin, and achieve the effect of treatment of this disease, oral bromocriptine can be taken once a day, each time 1.25 ~ 5mg, the side effects of which can be seen in nausea, vomiting, dizziness, upright hypotension, etc.; the use of danazol can inhibit the secretion of gonadotropins and ovarian hormones, can be used orally for the treatment of this disease, 3 times a day, each time 100mg, the course of treatment for 1 ~ 6 months, the side effects of which can be seen in Amenorrhea, menstrual dribbling, weight gain, acne and so on.
Small doses of iodine can stimulate the anterior pituitary gland to secrete luteinizing hormone, thus inhibiting the secretion of estrogen and correcting the imbalance of hormone ratios in the luteal phase, in order to achieve the purpose of treating breast hyperplasia.
Iodine preparations are commonly used as compound iodine solution or 10% potassium iodide solution.
Other symptomatic medications include analgesics and diuretics. In addition, vitamin drugs can also be taken.