Difenidol Hydrochloride

Pharmacology:

Pharmacodynamics

This product improves the insufficiency of blood supply to the vertebral basilar artery, and has a modulating effect on the vestibulary nervous system, and has a therapeutic effect on all kinds of central and peripheral vertigo, as well as antiemetic and inhibitory nystagmus, and anti-motor sickness. It also has a weak peripheral anti-M-choline effect.

Pharmacokinetics

This product is absorbed through the gastrointestinal tract, and the blood concentration reaches the peak 1.5 to 3 hours after taking the drug. The half-life is 4 hours. It is excreted in its original form in the urine.

[Pharmacological effects]This product has a dilating effect on spasmodic blood vessels, and can increase the blood flow of cerebral arteries, especially the radicular artery. In addition, this product can adjust the abnormal impulse of vestibular nerve, inhibit the vomiting center and improve nystagmus, so it can be used in patients with vertigo and vomiting. This product has no antihistamine effect, no sedative effect, no anesthesia-enhancing effect.

Pharmacokinetics

This product is orally absorbed by the gastrointestinal tract, the peak time of blood concentration is 1.5-3h, and the metabolites are excreted in urine.

Indications:

It is used for vertigo and vomiting caused by a variety of diseases (e.g., insufficiency of blood supply to the vertebral basilar artery, Meniere's disease, phytoneurological dysfunction, high blood pressure, low blood pressure, cervical vertigo, traumatic injuries, or drug toxicity), and vomiting after anesthesia of surgery; and it has a preventive and therapeutic effect on motion sickness.

This product is used for the treatment of vertigo caused by various reasons, such as vertebral basilar artery blood supply insufficiency, Meniere's disease, vegetative nerve function disorders, cervical vertigo and motion sickness. After clinical efficacy observation, its effective rate is more than 80%. The advantages of this product are high efficacy without adverse reactions such as drowsiness or over-excitement, no effect on the normal work of the personnel, and can be used as the main drug for the treatment of vertigo.

Use and dosage:

Adults commonly used oral, once 25-50mg, 3 times a day.

[Preparations and Specifications]Difenidol Hydrochloride Tablets 25mg

Orally, 25-50mg once, 3 times a day.

[Usage and dosage]Oral, 25-50mg each time, 3 times a day. Intramuscular injection, 10～20mg each time, 1～2 times a day.

[Dosage and specification]Tablet: 25mg/tablet. Injection: 10mg/ml.

Contraindications:

Because of the mild anti-M-choline effect of this product, it should be used with caution in glaucoma, gastrointestinal or urinary tract obstructive diseases, and tachycardia, and it is contraindicated in renal insufficiency.

Glaucoma patients with caution, severe renal impairment and allergy is contraindicated.

Adverse reactions:

Mainly dry mouth and mild gastrointestinal discomfort, which can disappear after stopping the drug. In addition, it has been reported that there may be hallucinations, hallucinations, disorientation, confusion, drowsiness, restlessness, depression and anti-M-choline effect, etc. Occasionally, transient hypotension, headache and skin rash can be seen.

Mainly dry mouth, stomach upset, a few patients have tinnitus, drug rash, cold feeling in hands and feet, loss of appetite, drowsiness, palpitations and so on. The total incidence of various side effects is about 10%. The occurrence of the above side effects does not affect the continuation of treatment. -They usually disappear after stopping the drug.

Interactions:

Taking Difenidol first reduces the emetic effect of apomorphine in the treatment of poisoning.

Combining this drug with other drugs that increase the blood supply to the brain may enhance its antivertigo effects.