Melatonin has side effects: for most adults, it is safe to use melatonin in small doses in the short term, but there is no strict experiment to confirm its safety in long-term use. The possible side effects mentioned are nausea, headache, diarrhea, joint pain, short-term depression, daytime sleepiness, dizziness, stomach cramps and so on.

A crowd observation pointed out that long-term use of melatonin and sleep AIDS may be related to the increased risk of fracture.

Six taboos of melatonin use:

1. If extra melatonin supplementation is considered due to sleep disorder, it is best to seek medical advice to confirm the related hormone levels and the causes of sleep problems;

2. It is not recommended for pregnant women, children, nursing mothers and people with liver and renal insufficiency, because the related safety is unknown;

3. Do not use it for patients with low blood pressure or taking antihypertensive drugs. Melatonin has the effect of lowering blood pressure, which may interfere with the action of drugs;

4. Do not use it with sleep sedatives (central nervous system inhibitors), which may lead to excessive sleepiness;

5. Don't use it in combination with caffeine, because caffeine may reduce the level of melatonin in the body, and if used together, it will reduce the effect of the supplement;

6. Do not use it with hypoglycemic drugs or insulin, which may affect the efficacy of sugar control drugs.