Beijing Zhongshan Hospital gastrointestinal diagnosis and treatment center experts introduced: ① sulfonamides: preferred gastrointestinal tract is not easy to absorb sulfonamides, which LiuZiSulphonpyridine (salicylic acid azo-sulphonamide pyridine) the best results. ② antibiotics: secondary infections can be used penicillin, chloramphenicol, gentamicin, cephalosporin, etc., in order to avoid aggravation of gastrointestinal symptoms, usually choose intravenous drugs. ③ Glucocorticoids and corticotropin (adrenocorticotropic hormone): recent efficacy is better, the effective rate of up to 90%, can inhibit inflammation and immune response, alleviate the symptoms of poisoning. ④Immunomodulatory drugs: for a few patients who are insensitive to glucocorticoid treatment or dependent on glucocorticoid, immunosuppressive drugs can be considered. ⑤ Other drugs: such as cromoglicic acid (disodium cromoglycate) can prevent mast cells, eosinophils from degranulation, thus inhibiting the release of 5-hydroxytryptophan, slow-reacting substances, reducing antigen-antibody reaction, which can alleviate the symptoms; calcium channel blockers, such as verapamil (ibogaine), nifedipine, guillotine and so on, can reduce intestinal secretion and alleviate diarrhea; the traditional Chinese medicine berberine (Huanglianxin), bitter ginseng, betulinum, yunnanbaiyao, Tin-like powder and so on to do local treatment has certain efficacy.　

EGF epidermal growth factor works by binding to the epidermal growth factor receptor (EGFR), a receptor on the cell surface. The high affinity binding to the EGFR receptor stimulates the receptor's intrinsic tyrosine kinase activity, which initiates a signaling cascade that affects a variety of biochemical changes, increases intracellular calcium levels, increases glycolysis and protein synthesis, increases the expression of certain genes (including EGFR), and ultimately promotes DNA synthesis and cell proliferation. It can effectively repair ulcer wounds, accelerate the healing of "ulcer knot", and at the same time improve the microcirculation of wounds, anti-bacterial and anti-inflammatory to eliminate edema and enhance the body's immune system to prevent cancerous changes.