1 HBsAb
2 HBeAg
3 HBeAb
4 HBcAb
5 The analysis of the common results of two and a half pairs of hepatitis B is commonly known as 01-◆ Never been infected with HBV in the past and now. Hepatitis B is half-negative 02-+1.Previous infection failed to detect anti-HBS; Two and a half pairs of hepatitis B are 5 positive 03-++1.They have been infected with HBV； before;
2. Recovery period of acute HBV infection;
3. A few specimens are still infectious. Two pairs of hepatitis B are 45-positive 04-+-1.After being injected with hepatitis B vaccine, there is immunity;
2. Past infection;
3. Two pairs of false positive HBV and two pairs of false positive HBV 05-+-++have been infected with HBV in the past, and have been cleared, and protective antibodies have appeared. Two pairs of hepatitis B are 245 positive 06+-+1.Acute HBV infection;
2. Chronic HBsAg carriers;
3. The infectivity is weak. Two and a half pairs of hepatitis B 15 are positive for 07-+-+1.They have been infected before and still have immunity.
2.HBV infection, recovery period. Two pairs of hepatitis B are 25+08+-++1.Acute HBV infection tends to recover;
2. Chronic HBsAg carriers;
3. The infectivity is relatively weak. Two and a half pairs of hepatitis B 145 were positive;
It is commonly known as "Xiao Sanyang". 09+-+-+Acute or chronic hepatitis B infection. It is suggested that HBV replication is highly contagious. Two and a half pairs of hepatitis B 135 positive.
Commonly known as "Big Three Yang". Clinical significance analysis of hepatitis B in two halves: 16 rare pattern serial numbers HBsAg
1 HBsAb
2 HBeAg
3 HBeAb
4 HBcAb
5. Analysis of the common results of hepatitis B, commonly known as10+-1.Early stage of acute HBV infection and incubation period of acute HBV infection; 2. Chronic HBV carriers are weak in infectivity. Two halves of hepatitis B 1 positive1+-+-1.Chronic HBsAg carriers are easy to turn negative; 2. Acute HBV infection tends to recover. Two and a half pairs of hepatitis B 14 positive12+-+-early or chronic carriers of acute HBV infection are highly contagious. Two halves of hepatitis B 13 positive13+-++1.Acute HBV infection tends to recover; 2. Chronic carriers. Two halves of hepatitis B 1345 positive14++-1.Early subclinical HBV infection; 2. Secondary infection of different subtypes of HBV. Two halves of hepatitis B 12 positive15++-+1.Early subclinical HBV infection; 2. Secondary infection of different subtypes of HBV. Two and a half pairs of hepatitis B 125 positive16++-subclinical or atypical infection. Two halves of hepatitis B 124 positive 17++-++subclinical or atypical infection. 18++-+1.Early subclinical or atypical infection. 2.HBsAg immune complex, new different subtypes of infection. 19-+-1.atypical acute infection; 2. In the early stage of infection before anti -HBc appeared, HBsAg titer was low and negative, or false positive. Two-and-a-half pairs of hepatitis B, 3 positive, 20-+-+atypical acute infection. 21-+++acute HBV infection in the middle stage. 22-+-+-HBV infection has recovered. 23-++-atypical or subclinical HBV infection. 24-++-+atypical or subclinical HBV infection. 25-+-Acute HBV infection tends to recover. Two-and-a-half pairs of hepatitis B 135 positive, commonly known as hepatitis B big three positive in medicine, generally means that hepatitis B virus replication in the body is active and relatively contagious. However, the two-and-a-half 135 positive hepatitis B patients can not explain the severity of the disease and the degree of liver damage. It is necessary to further check the liver function, liver B-ultrasound and hepatitis B virus load DNA, and comprehensively analyze and judge the severity of the disease, the replication of hepatitis B virus and the infectivity, and determine the appropriate treatment plan according to the situation, so as to achieve targeted medication and standardized treatment.
Hepatitis B is positive in half 135. If the liver function is normal, there are no other clinical symptoms, and there is no obvious liver damage in various B-ultrasound tests, it is suggested to observe dynamically, and HBV serological and liver function biochemical indexes and B-ultrasound tests should be carried out every 3-6 months.
Two and a half pairs of hepatitis B are positive for kloc-0/35. If the liver function is abnormal, the transaminase is more than 2 times normal, and HBV-DNA is positive, which often indicates that the chronic hepatitis is active, that is, immunity has started. At this time, we should grasp the treatment opportunity and need to carry out antiviral and liver protection treatment under the guidance of professional doctors.
Two-and-a-half pairs of hepatitis B 145 positive means that hepatitis B surface antigen, E antibody and core antibody are positive in blood tests, which we call hepatitis B small three-positive.
Any two-and-a-half pairs of hepatitis B 145 positive (small three-positive hepatitis B) indicates acute or chronic hepatitis B, and the virus replicates in the body, which is the state of hepatitis B virus replication.
If hepatitis B is half 145 positive, you should further check your liver function, blood routine, alpha-fetoprotein and B-ultrasound, so that you and your doctor can understand the changes of your condition. Two and a half pairs of hepatitis B 145 positive (hepatitis B small three positive) tests showed that HBVDNA was still positive, indicating that hepatitis B virus still existed and was still contagious. Where the transaminase is high and the virus is active, the active small sanyang needs treatment. Otherwise, the liver will develop towards fibrosis-cirrhosis-liver cancer.
In addition, two and a half pairs of hepatitis B 145 are positive, HBV-DNA is negative, and liver function is normal. Many people think that treatment is not needed. However, through liver biopsy, it is found that 90% patients have chronic inflammatory activities in the liver, and there is a tendency of liver fibrosis. Some patients even have early cirrhosis, the most serious of which is canceration. This part of hepatitis B patients with small three positive should consider anti-fibrosis treatment.
Two-and-a-half pairs of hepatitis B 15 positive, which is what we usually call hepatitis B small two-yang, indicates that the patient's infectivity is weak. If the patient has acute or chronic hepatitis, it indicates that the patient is still contagious. If it is transformed from hepatitis B small three-yang, it indicates that the virus replication tends to stop and the infectivity is small. As long as the liver function and hepatitis B are checked regularly, as long as the liver function is normal, patients don't have to worry too much.
HBsAg in item 1 of item 5 of hepatitis B is positive, indicating that there is hepatitis B virus in the body and it is being infected now; The fifth item of the fifth item of hepatitis B is HBcAb positive, indicating that it has been infected by hepatitis B virus.
To judge the severity of hepatitis B, we should not only check five items of hepatitis B (two and a half), but also combine liver function test, liver fibrosis index and B-ultrasound and CT findings to make a more accurate judgment. Hepatitis B 15 is positive, so it is suggested to do further liver function and HBV－DNA examination, and take corresponding measures according to the examination results.
Two halves of hepatitis B are positive for 245, which means that hepatitis B surface antibody, E antibody and core antibody are positive. Hepatitis B surface antibody is an antibody produced after the surface antigen of hepatitis B virus stimulates the human immune system, which can protect the human body from the second attack of hepatitis B virus.
Whether two pairs of hepatitis B are positive for 245 is contagious depends on the examination of liver function, HBV-DNA and liver B-ultrasound to determine whether there is virus replication. If the patients with 245 positive in both halves of hepatitis B have normal liver function and DNA negative without virus replication, they will not infect hepatitis B virus; Very few people can have 245 positive hepatitis B, but HBV-DNA is positive, and the virus replicates, so it is possible to infect hepatitis B virus. In the two-and-a-half examination of hepatitis B, it is often seen that all five items of hepatitis B are negative. It can be said that it is a good phenomenon if all five items of hepatitis B are negative in someone's examination, but it is not the most ideal state. So what if all five items of hepatitis B are negative?
The negative results of the five items of hepatitis B indicate that there is neither hepatitis B virus nor hepatitis B antibody, and the inspector should be vaccinated with hepatitis B vaccine in time. And after the whole course of vaccination with 3 doses of vaccine, check two halves of hepatitis B again to see the titer of antibody produced. If it is less than 10 μ g, it is necessary to vaccinate with booster vaccine.
There is another situation in which all five items of hepatitis B are negative. Experts explained that some people's five items of hepatitis B are all negative but caused by virus variation. Therefore, after checking all five items of hepatitis B, it is best to check hepatitis B virus DNA and virus variation detection to see if there is virus variation.
Generally speaking, what to do if all five items of hepatitis B are negative is to do another viral DNA test. If there is no hepatitis B virus in the test, it is necessary to inject hepatitis B vaccine in time according to the principle of 0,/kloc-0, and 6. If the DNA test is positive, it will start the road of fighting against hepatitis B virus, and regular review and active treatment are the last word. The difference between hepatitis B and liver function test is one: the examination indexes are different.
(1) Project indicators are five items of hepatitis B, namely: surface antigen (HBsAg) and surface antibody (anti-HBs or HBsAb), e antigen (HBeAg) and e antibody (anti-HBeAg or HBeAb), and core antibody (anti-HBc or HBcAb).
(2) The indexes of routine examination of liver function are alanine aminotransferase (ALT), aspartate aminotransferase (AST), aspartate aminotransferase (AST/ALT), glutamyltransferase (GGP), alkaline phosphatase (ALP), total bilirubin (TBILI), direct bilirubin (DBILI), indirect bilirubin (IBILI) and total protein. GLB), glucose (GLU), urea nitrogen (BUN), creatinine (CRE), lactate dehydrogenase (LDH-L), creatine kinase (CK), total cholesterol (CHOL), triglyceride (TRIG) and uric acid (UA).
The difference between hepatitis B and liver function test: the clinical significance is different
1.The significance of the two-and-a-half hepatitis B examination is to check whether hepatitis B is infected and the specific situation of infection, and to distinguish between big three-yang and small three-yang diseases.
2. Liver function reflects the physiological function of the liver. Liver function examination is to detect whether there is any disease in the liver, the degree of liver damage, find out the cause of liver disease, judge the prognosis and identify the cause of jaundice. Liver function examination is especially sensitive and important for judging liver diseases, such as hepatitis and cirrhosis.
(1) HBsAg-positive hepatitis B surface antigen is the antigen of the outer membrane of hepatitis B virus, and it is the earliest hepatitis B virus marker in serum. The positive results suggest that carriers of HBsAg in the early stage of acute infection or chronic infection are contagious.
(2) Positive surface antibody (anti -HBs) indicates that it has developed immunity to hepatitis B virus, and it is a friendly substance. Positive surface antibody indicates that it has been infected with hepatitis B in the past or vaccinated with hepatitis B vaccine, and now it has developed immunity.
(3) The positive of hepatitis B virus E antigen (HBeAg) indicates that hepatitis B virus is replicating and infectious, which may be an early acute infection of hepatitis B virus. The higher the DNA level of hepatitis B virus, the higher the positive level of E antigen. The long-term positive results in two halves of hepatitis B suggest that hepatitis B virus continues to replicate in the body, liver inflammation is chronic and the prognosis is poor.
(4) Positive antibody to hepatitis B virus E (anti -HBe) is a sign of hepatitis B virus infection, which usually appears after the disappearance of hepatitis B E antigen. Its existence suggests that hepatitis B virus infection has entered the late stage, when the virus replication has decreased and its infectivity has weakened. Recovery period after hepatitis B virus infection or chronic infection can be positive.
(5) Positive core antibody IgM (anti-HBc-IgM) indicates acute hepatitis B virus infection, which is also a sign of hepatitis B virus replication and infectivity. Acute hepatitis B, chronic hepatitis B and liver cirrhosis can all be positive.
liver function
Normal reference value of project unit
Alanine aminotransferase (alt) iu/l (1~ 38)
Ast iu/l (8 ~ 40)
Alkaline phosphatase (ALP) iu/l (100 ~ 275)
R- transpeptidase (GGT) iu/l (9 ~ 40)
Total bilirubin (tbil) umol/l (4 ~ 20)
Direct bilirubin (DBIL) umol/L (0 ~ 7)
Clinical significance:
ALT (alanine aminotransferase), AST (aspartate aminotransferase), ALP (alkaline phosphatase), GGT(r- transpeptidase) and test results were significantly increased, reflecting abnormal liver function (damage). The increase of TBIL (total bilirubin) suggested jaundice, which was caused by biliary obstruction. The common causes are biliary stones, biliary ascariasis, biliary obstruction caused by biliary tumors, or compression of pancreatic head tumors and invasion of common bile duct.
5. Half-and-half test of hepatitis B 2
normal
Negative surface antigen (HBsAg)
Negative or positive surface antibody (anti -HBs)
E antigen (HBeAg) negative
Anti -HBe negative
Core antibody (anti -HBc) is negative. Most hepatitis B patients and a considerable number of medical workers judge the severity of hepatitis B by the results of two and a half tests of hepatitis B, such as "big three yang" and "small three yang", and regard whether the "three yang" turns negative as the only indicator of good or bad curative effect, which is extremely wrong.
Neither "Big Three-yang" nor "Small Three-yang" can explain or judge the severity of hepatitis B. It can only explain that hepatitis B virus is carried in the body and the replication of the virus, and it cannot explain the seriousness of the virus, nor can it represent the degree of liver disease or reflect the curative effect. The condition and basis for judging and dividing the severity of hepatitis B is the systematic liver function test results.