At present, it may be difficult to make all the antigens of "Xiao Sanyang" turn negative. Some people say that the so-called negative transformation is only through the reduction of virus content in the body and the negative transformation of DNA after treatment.

"Small Sanyang" must also be treated.

Most patients with hepatitis B "Xiao Sanyang" have this experience: some experts told him that "Xiao Sanyang" does not need treatment, and some experts told him that "Xiao Sanyang" needs treatment, which is more harmful and easier to turn into cirrhosis and liver cancer. Therefore, patients are often confused. Who should they listen to?

To clarify whether hepatitis B "small three-yang" needs treatment, we must first clarify whether the people with "small three-yang" belong to healthy people. It should be said that people with "small three yang" are not healthy people, and different treatment schemes should be adopted according to the infection type of patients, the inflammatory activity of liver, the changes of liver function and whether HBV DNA is negative or positive. The experts who think that no treatment is needed are based on the fact that there is no very effective drug for "Small Sanyang" in the past, especially when interferon is ineffective for "Small Sanyang" patients, they have no choice. If "small three-positive" and HBV DNA are positive, and liver function tests fluctuate repeatedly, it is often called atypical hepatitis in clinic, mainly caused by HBV mutation, and antiviral treatment must be carried out. However, due to the poor curative effect of interferon, and interferon itself will cause virus variation, it can not be used for the treatment of patients with "small three-positive". If it is "small three-positive", and the hepatitis B virus DNA is negative and the liver function is normal, many doctors think that treatment is not needed, but through liver puncture, it is found that 90% of patients have inflammatory activities and fibrosis tendency, and even some patients have early cirrhosis, so these patients should consider anti-fibrosis treatment. Most patients over 40 years old with a course of 10 years have different degrees of liver fibrosis. Active and effective treatment is of great significance to prevent the occurrence and development of liver cirrhosis, improve the prognosis of patients and improve their quality of life.

The situation of patients with small sanyang is not simpler than that of patients with large sanyang; Comprehensive analysis should be carried out according to the specific situation. Patients with hepatitis B should be examined for HBV- Dan and liver function. If HBV- Dan (+) and liver function are abnormal, it means that the virus is highly contagious and should be treated with comprehensive antiviral therapy. If both halves of hepatitis B are small three-positive, HBV- Dan (PCR and dot method should be used for simultaneous detection; It is best to confirm the diagnosis by liver biopsy)) is (-) and the liver function, B-ultrasound and AFP are normal for a long time, indicating that the virus has been eliminated and is not contagious, so isolation treatment is no longer needed; Because there is no recognized effective drug to further treat hepatitis B on the basis of this small three-yang; Blindly taking a large number of therapeutic Chinese and western medicines after turning negative will only increase the burden on the liver and even lead to adverse consequences. If the liver continues to be inflamed, the probability of cirrhosis is high; Lycium barbarum can't be drunk in wine

In China, there are more patients with hepatitis B "small three-yang", accounting for about 30% of the total number of hepatitis B. In the past, it was thought that the change from "big three-yang" to "small three-yang" meant that the virus replication was weakened, the infectivity was small and the condition improved. This understanding is one-sided and flawed. "Small Sanyang" patients must be treated differently, and whether they need treatment or not depends on the specific situation.

In theory, all patients with "small three yang" should be treated. However, from the current actual situation, it should be treated differently, some need timely treatment, and some do not need treatment. The existence of hepatitis B "Little Three Yang", no matter in what form, is a potential threat to human health, and there is no doubt that it can be completely eliminated in time. For many years, medical workers have been committed to this work, but the results are not great. Some "Xiao Sanyang" have long-term stable liver function and no obvious discomfort, but they are eager to turn negative for treatment. They spent a lot of money but didn't turn it around, and some of them are getting worse. Some patients with "Xiao Sanyang" have long-term fluctuations in liver function, but they can't get correct treatment, which leads to the gradual development of the disease and eventually evolves into cirrhosis.

Under the following circumstances, patients with "Xiao Sanyang" need timely treatment.

1. has obvious symptoms, such as fatigue, loss of appetite, abdominal distension and liver discomfort.

2. Liver function fluctuates repeatedly, transaminase and serum bilirubin increase, albumin decreases, etc.

3. HBV DNA test is positive.

The principle of treatment is to restore liver function, resist virus and prevent liver fibrosis.

The treatment method is:

1. Oral lamivudine (antiviral), one tablet per day (100 mg), 6 ~ 12 months as a course of treatment;

2. Oral compound Biejia Ruangan tablets (to prevent liver fibrosis), 4-5 tablets twice a day, 6 times in total.

12 months is a course of treatment;

3. Take Gandening orally, twice a day, 2 capsules each time, 6 to 12 months as a course of treatment. The combination of the above three drugs has better curative effect.

Under the following circumstances, patients with "Xiao Sanyang" may not be treated for the time being.

1. The body has no obvious discomfort, and its physical strength and appetite are the same as those of normal people.

2. A series of liver function tests remained normal for a long time.

3. Regular review of HBVDNA is always negative. These people can be treated without drugs, but non-drug therapy is worth a try, such as sports and leisure therapy, psychological rehabilitation therapy and so on. The purpose is to maintain a good attitude, self-adjust the law of life, mobilize their own potential, and eliminate diseases.