The prescription Danggui Sini Decoction is classified from Treatise on Febrile Diseases as a warming agent-warming meridians and dispelling cold, which consists of Danggui (12g), Guizhi (9g), Paeonia lactiflora (9g), Asarum (3g), Tongcao (6g), Jujube (8 pieces, broken [bo]) and roasted licorice (6g). Indications: blood deficiency and cold Jue syndrome. Cold hands and feet, or pain in waist, thighs, legs, feet, shoulders and arms, thirst in mouth, pale tongue with white fur, heavy or thin pulse and heartbroken. (This prescription is commonly used for thromboangiitis obliterans, pulseless disease, Raynaud's disease, polio, chilblain, dysmenorrhea, scapulohumeral periarthritis, rheumatoid arthritis, etc. ) There are seven flavors in usage: eight liters of water, three liters of boiled water, and none of me. Take one liter warm, three times a day (modern usage: decoction. ) taboo consideration. Fang Jie's syndrome is caused by weak blood, cold coagulation of meridians and unfavorable blood circulation. Deficiency of blood in the body and cold in the meridians, stagnation of cold pathogen, unfavorable blood circulation, inability of yang to reach the extremities, inability of nourishing blood to fill the blood vessels, resulting in cold hands and feet and thin pulse. This hand and foot syncope is only refers to the palm to the wrist and ankle is not warm, and it is different from the limbs syncope. Treatment should be warming meridians to dispel cold, nourishing blood and dredging veins. This prescription consists of Guizhi decoction with ginger removed, jujube doubled and angelica sinensis, medulla tetrapanacis and asarum added. Angelica sinensis in the prescription is sweet, nourishing blood and blood; Guizhi is a monarch drug, which is pungent and warm, warms meridians to dispel cold, and warms blood vessels. Asarum warms meridians to dispel cold, and helps Guizhi warm and dredge blood vessels; Radix Paeoniae Alba nourishes blood and nourishes blood, and helps Angelica sinensis replenish blood. * * * is a minister medicine. Tong Cao tong meridian, in order to smooth blood circulation; Jujube, licorice, invigorating qi, invigorating spleen and nourishing blood, * * * as adjuvant drugs. Reuse jujube, not only for nourishing blood, but also to prevent the branches and asarum from being too dry and hurting yin and blood. Glycyrrhiza uralensis Fisch has both medicinal properties and is used as a medicine. The whole prescription * * * plays the role of warming meridians to dispel cold, nourishing blood and dredging veins. The compatibility of this prescription is characterized by warming yang and dispelling cold, nourishing blood and dredging veins, warming without dryness, and nourishing without stagnation. If the pain of waist, thigh, leg and foot is caused by blood deficiency and cold coagulation, Radix Dipsaci, Radix Achyranthis Bidentatae, Caulis Spatholobi, Fructus Chaenomelis and other products for promoting blood circulation and removing blood stasis can be added as appropriate. If Evodia rutaecarpa ginger is added, it can cure the chronic cold and vomiting caused by drinking water. If it is used to treat menstrual abdominal pain due to blood deficiency and cold coagulation in women, and cold hernia in men, testicular pain, abdominal pain due to traction, and cold pulse in limbs, Lindera root, fennel, Alpinia officinarum and Rhizoma Cyperi can be added to regulate qi and relieve pain. If frostbite of hands and feet is caused by blood deficiency and cold coagulation, whether it is not ulcerated or ulcerated at the initial stage, this recipe can be modified. The attached prescriptions Danggui Sini plus Evodia rutaecarpa and Ginger Decoction (Treatise on Febrile Diseases) and Huangqi Guizhi Wuwu Decoction (Synopsis of the Golden Chamber) are commonly used prescriptions for nourishing blood, warming meridians and dispelling cold. Clinical application is based on syncope of hands and feet, pale tongue with white fur and thready pulse. Comparison of prescriptions: The prescriptions named after "Sini" in Treatise on Febrile Diseases include Sini Powder, Sini Decoction and Danggui Sini Decoction. There are "four adverse reactions" in all three indications, but their pathogenesis and medication are quite different. Sini San syndrome is caused by exogenous pathogenic factors spreading into the meridian and yang qi being depressed in the interior, so its adverse cold is only at the extremities, but not at the wrists and ankles, and symptoms such as body heat and pulse string can be seen. The syncope of Sini Decoction is caused by yin-cold overflowing, yang-qi failing, and inability to reach the end of four seasons, so its syncope is serious, and it is too cold to elbow and knee, accompanied by symptoms such as drowsiness, abdominal pain, weak pulse and so on. The cold syncope of hands and feet of Danggui Sini Decoction is caused by blood deficiency and cold, cold congealing meridians and poor blood circulation. Because of its cold pathogen in meridians but not dirty, the degree of limb syncope is lighter than that of Sini Decoction syndrome, and symptoms such as limb pain are also seen. Therefore, the drugs and functions of the three parties are completely different, as Zhou Yangjun said: "Sini decoction is all for the purpose of returning to Yang, Sini powder is all for the purpose of reconciliation, and Danggui Sini decoction is all for the purpose of nourishing blood and dredging veins." Danggui Sini Decoction, Danggui Sini plus Evodia rutaecarpa Ginger Decoction and Huangqi Guizhi Wuwu Decoction all evolved from Guizhi Decoction. Among them, Danggui Sini Decoction is mainly used for treating cold due to blood deficiency, cold and pain of hand and foot channels due to cold coagulation of meridians; If the syndrome of Danggui Sini decoction is accompanied by vomiting and abdominal pain, the cold pathogen is in the stomach, so Danggui Sini plus Evodia rutaecarpa ginger decoction should be used. Huangqi Guizhi Wuwu Decoction is mainly used for treating blood arthralgia caused by weak body, slight exposure to wind evil, stagnation of blood vessels and stagnation of blood. On the literature, Xu Hong's "Discussion on the Prescriptions in the Golden Mirror" Volume 7: "Yin and blood are deficient, so you can't be proud of the pulse; If the yang is deficient, it can't be warmed at the end of the four seasons, so the hands and feet are cold and the pulse is thin. Therefore, angelica is used as the monarch to replenish blood; Taking Paeonia lactiflora as the minister, supplemented by nourishing the qi; Taking the suffering of cassia twig and asarum as an aid, dispelling cold and warming qi; Taking the sweetness of jujube and licorice as the guide, we can benefit from it and make up for its deficiency; With the lightness of the grass, it passes through its veins and sputum. " Treatise on Treatise on Febrile Diseases and Syndrome Differentiation of Jueyin: "Danggui Sini Decoction is the main treatment for those with cold hands and feet and heartbroken pulse."