Ingredients: this product is a compound preparation, and its components are: metronidazole 200mg, artificial bezoar 5mg.

Indications: periapical periodontitis, dental diseases, pulpitis, periapical diseases, recoverable pulpitis, acute pulpitis, periodontitis, irreversible pulpitis and pericoronitis of wisdom teeth.

Indications: Metronidazole has a strong antibacterial effect on most anaerobic bacteria, but it has no effect on aerobic bacteria and facultative anaerobic bacteria. The antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Fusobacterium, Clostridium aerogenes, Eubacterium, Veillococcus, Digestive coccus and Digestive Streptococcus. Actinomyces, Lactobacillus and Propionibacterium are resistant to this product. Its bactericidal concentration is slightly higher than the bacteriostatic concentration. In addition, it has a strong killing effect on amoeba and trichomonas. The bactericidal mechanism of metronidazole has not been fully clarified, and nitroreductase of anaerobic bacteria plays an important role in energy metabolism of sensitive strains.

This product is mainly used for acute wisdom tooth pericoronitis, local alveolar abscess, pulpitis and periapical periodontitis.

Administration and dosage: Take orally, 2 capsules at a time, 3 times a day.

Specification: metronidazole 0.2g, artificial bezoar 5mg.

Adverse reactions: 1. The most serious adverse reactions of this product are epilepsy and peripheral neuropathy caused by high dose. The latter is mainly manifested as numbness and paresthesia of extremities. In some cases, persistent peripheral neuropathy can be caused by long-term medication.

2. Other common adverse reactions are:

(1) Gastrointestinal reactions, such as nausea, anorexia, vomiting, diarrhea, abdominal discomfort, taste change, dry mouth, metallic taste in the mouth, etc.

(2) Reversible granulocytopenia.

(3) allergic reaction, rash, urticaria, itching, etc.

(4) Central nervous system symptoms, such as headache, dizziness, syncope, paresthesia, numbness of limbs, ataxia and insanity.

(5) Others, such as fever, vaginal candidiasis, cystitis, dysuria, and dark urine, are reversible. They will recover after stopping taking the drug.

Note:

1. Disabled for patients allergic to metronidazole or pyrrole drugs.

2. Patients with active central nervous system diseases and hematological diseases are prohibited.

3. Pregnant women are forbidden.

4. It is forbidden for drinkers.

Taboo:

1. Carcinogenic and mutagenic effects: Animal tests or in vitro tests show that this product has carcinogenic and mutagenic effects, but it has not been confirmed in human body.

2. Adverse reactions of the central nervous system occur during use. The drug should be stopped in time.

3. This product can interfere with the test results of alanine aminotransferase, lactate dehydrogenase, triacylglycerol, hexokinase, etc., and reduce the measured value to zero.

4. Alcoholic beverages should not be drunk during medication, because it may cause acetaldehyde accumulation in the body, interfere with the oxidation process of alcohol, and lead to disulfiram-like reaction. Patients may have abdominal cramps, nausea, vomiting, headache, facial flushing, etc.

5. The metabolism of this product is slowed down in patients with liver dysfunction. Drugs and their metabolites are easy to accumulate in the body. They should be used in a reduced amount and the blood drug concentration should be monitored.

6. This product can be continuously removed from gastric juice. Some people who put a gastric tube for suction and decompression can cause the blood drug concentration to drop. During hemodialysis, this product and metabolites are quickly removed. Therefore, it is not necessary to reduce the dosage of this product.

7. Candida infection patients should use this product. Their symptoms will get worse. At the same time, they should be given antifungal treatment.

8. Patients with anaerobic bacterial infection complicated with renal failure. The interval of administration should be extended from 8 hours to 12 hours.

9. When treating vaginal trichomoniasis, you need to treat your sexual partner at the same time.

10. White blood cell count should be done before repeating a course of treatment.

Medication for pregnant and lactating women

Metronidazole can penetrate the placenta and quickly enter the fetal circulation. Animal experiments have found that oral administration has no toxicity to fetuses. The effect of metronidazole on the fetus has not been sufficiently and closely observed, so pregnant women are prohibited. The concentration of metronidazole in milk is similar to that in blood. Animal experiments show that this product has carcinogenic effect on young mice, so it is not suitable for lactating women. If medication is necessary, breast-feeding should be interrupted and breast-feeding can be resumed 24 ~ 48 hours after the end of the course of treatment.

Children's medication: children should use it with caution and reduce it.

Medication for the elderly: the pharmacokinetics of this product has changed in the elderly due to liver function decline, so it is necessary to monitor the blood drug concentration.

Drug interaction:

Metronidazole has a powerful effect on most anaerobic bacteria. Antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Actinobacillus, Bacteroides aerogenes, Eubacterium, Veillococcus, Digestive coccus and Digestive Streptococcus. Its bactericidal concentration is slightly higher than its bacteriostatic concentration. The bactericidal mechanism of metronidazole has not been fully clarified. Nitrate reductase of anaerobic bacteria plays an important role in the energy of sensitive strains. Promote the death of bacteria. Drug-resistant bacteria often lack nitro and reducing acid, so they are resistant to metronidazole. Artificial bezoar has antipyretic and anti-inflammatory effects.

To sum up, artificial bezoar and metronidazole can affect the "liver function" of physical examination.