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(ii) Pharmacological effects

Antihypertensive. Stinking sycamore has antihypertensive effects on anesthetized or unanesthetized rats, rabbits, cats and dogs, as well as rats and dogs with renal hypertension. Water infusion and decoction have the strongest effect, followed by running ointment, and ethanol, ether and chloroform leachate are ineffective. Intramuscular, intravenous and oral administration can lower blood pressure. Heat infusion and extract (heat infusion alkalized with calcium chloride precipitation) to the dog intravenous injection shows two degrees of antihypertensive effect, the first degree of action is strong and short, immediately after injection, 30 - 60 minutes recovery, the second degree of action is mild and long-lasting; intramuscular injection and oral only cause the second degree of antihypertensive effect, can be maintained for 2-3 hours, intravenous injection of the decoction only appeared in the first degree of antihypertensive effect, oral ineffective. Intramuscular injection and oral administration caused only the second antihypertensive effect, which lasted for 2-3 hours. The first antihypertensive effect is probably not unique to Haizhou Changshan, and seems to have no practical significance in treatment. The antihypertensive effect of the leaves of Haizhou Changshan was better in those collected before flowering than in those collected after flowering. The antihypertensive effect of the leaves collected at the time of fruiting or aged in the next year is very slight. The effectiveness is also reduced by heating for too long. If used in combination with dillon, it has a synergistic effect on lowering blood pressure.

On the antihypertensive principle of this product, initially thought to be mainly due to direct vasodilatation, ganglion blockade also has a certain effect. Some people believe that it is mainly due to the stimulation of intravascular receptors through the center to lower blood pressure (cross-circulation and Pruca trap closure test) and vasomotor center excitability is reduced. It has also been suggested that all of these factors play a role. A more comprehensive view is that the first hypotensive effect is closely related to direct vasodilatation and blockade of the vegetative ganglion, and that reflexes may also be involved. The second degree of antihypertensive effect is likely to be caused by the action of the central nervous system above the spinal cord to cause part of the visceral vasodilatation, and has a certain relationship with some of the endoreceptors.

Experimentally, it was proved that odorata sylvestris A has obvious sedative effect, mild sedation, and increasing the dose does not cause sleep, and can prolong the anesthesia time of pentobarbital sodium.

Animal experiments have proved that the decoction of this product has significant analgesic effect, and the active ingredient is odoriferous sycamorein B.

This product and the ghost needle grass equivalent combination and dilute tung pills. Formaldehyde or egg white "arthritis" in rats has a significant inhibitory effect.

It has a certain antimalarial effect.

(C) the odor of the sycamore flavor attribution

Taste pungent, bitter, sweet, cool.

① "Herb and Tree": "sweet,"

② "Chongqing Herbal Medicine": "light flavor, flat, non-toxic."

Attributed to the liver, gallbladder and spleen meridians.

Functions and Indications Dispel wind-dampness, harmonize blood vessels, and open meridians. Treating rheumatism and joint pain, intestinal wind and blood, menstrual disorders, bruises.

① "Herb and Tree": "Harmonizing blood, dispelling wind, removing dampness, and clearing the channels. Treatment of women vomiting blood, menstrual disorders, lumbar and knee paralysis."

② "Lingnan medicinal record": "Suffering from flowers and willow poison bone pain, and pork boiled in soup."

③ "Chongqing Herbal Medicine": "Treatment of intestinal wind and blood."

(D) stinking wutong with the application

with Siegesbeckia, treatment of paralysis for a long time, lumbar and knee pain, limb flexion and extension of the unfavorable, or numbness, fear of cold and love of warmth. This is due to the wind, cold, dampness, three gas detention does not go, Ying Wei are weak due to. Suwen - paralysis theory" said: "paralysis in the bone is heavy, in the internal is not benevolent." "Su wen - the theory of counter-regulation" also said: "camp gas is not benevolent, Wei gas is not used, camp and Wei are weak, then not benevolent and not used." When searching for wind and dampness to stop paralyzing pain, replenish qi and blood, and Yingwei. Stinking wutong, dispel wind evil to win dampness, Sundaruta grass benefit qi and blood and yingwei, the two medicines used together, both the symptoms and the root cause, can make the qi and blood enough and wind and dampness to go, yingwei and paralysis and pain healing.

With Weilingxian, it can dissipate wind-dampness around the body and relieve joints and paralysis. This evidence is mostly due to sweating when the wind, or living in a humid place for a long time, wind, cold and dampness, caused by the surface of the muscle, the symptoms of shoulder and back pain can not be recalled, headache, body weight, or waist pain, difficult to turn around, moss and white veins floating. Stinking wutong, Wei Ling Xian, all have the function of dispelling wind and winning dampness. After serving, slightly sweat, so that the wind-dampness is gone, the pain is stopped.

With hook vine cools the liver and quenches the wind, soothes the tendons and activates the collaterals. It is very suitable for treating hyperactivity of liver yang, resulting in headache, dizziness and tremor. Crocus sativus cools the liver and quenches the wind, clearing heat and relieving spasm, the two medicines must be used to treat the wind and also treat the blood. Blood line wind since no.

With chrysanthemum, the treatment of liver yang hyperactivity, liver wind up disturbance, due to headache, dizziness, insomnia. Chrysanthemum to calm the liver and quench the wind, stinking wutong to clear heat and cool the blood, a treatment of wind, a treatment of blood, blood cool wind extinction, combined to calm the liver and quench the wind of a good pair.

With Fritillaria, the two drugs are used together, the function of specializing in the interception of malaria. Stinking wutong, "Tu Jing Materia Medica" eye: "malaria", fishy grass, "Compendium of Materia Medica" said: "cut off malaria", the former named because of the fishy flavor, the latter is incomparable to the stench, the two drugs together, and Shaoyang, and the obscenity, malaria killers, and the treatment of "warm malaria", "malaria", "malaria", "malaria", "malaria", "malaria", "malaria", "malaria", "malaria", "malaria". It is the most effective treatment for "warm malaria".

With honeysuckle to clear heat and detoxify, eliminate carbuncles and treat sores. It is used for carbuncles and boils with fire-poison accumulation, initially localized redness, swelling and hot pain, or fever and malignant cold, and for a long time accumulation of stagnation and heat, and flesh rotting into pus. The combination of the two drugs can clear heat and detoxify, cool blood and disperse knots, and canker sores can be cured.

With Huanglian, hot dysentery, heat detoxification, cooling blood to stop dysentery, hot dysentery is dysentery abdominal pain. The hot dysentery is dysentery and abdominal pain. After the acute and heavy, burning anus, this product has Huanglian clearing dampness and heat, thick stomach and intestines, so that the heat clearing and detoxification, dysentery stops and the heavy after the self-removal.

Formulas

Xitong Pill ("Nutritional Experience Collection"): ground paulownia (flowers, leaves, stalks, seeds can be taken, chopped, dried, ground seeds) 500 grams, Sundaruta grass (fried, ground) 240 grams. The above two flavors and even, refined honey pills, such as sycamore seeds large, morning and evening to the white boiling soup sent down l2 grams. Avoid eating pig liver, sheep blood and other things. Or single stinking sycamore 60 grams, decoction soup drink, to wine over the l0 dose, or decoction soup wash hands and feet can also be. The treatment of men and women feel the wind and dampness, or drink the wind, so that the two feet soft and sore pain, can not walk, or two hands to trip, can not be lifted up.

Treatment of hypertension ("National Herbal Medicine Compendium"): 6 grams of stinking wutong leaves, wild buckwheat root, Xiaku Cao (flower spikes), 30 grams of capsicum, XuanShen, raw rhizoma, fire charcoal mother (small halo medicine) 15 grams each. Decoction with water, 3 times a day. If the mouth is bitter, add 9 grams of gentian grass; insomnia, add 30 grams of nightshade, 15 grams of acacia.

Treatment of rheumatic pain, bone joint pain and hypertension ("Shanghai Commonly Used Chinese Herbs"): 9 grams of this product -30 grams. Decoction; powder 3 grams per dose, 3 times a day.

Treatment of all internal and external hemorrhoids ("Herbal Compendium Gleanings"): stinking sycamore leaves 7 pieces, 7 branches of pine, 9 grams of nitrous oxide. Decoction and fumigation.

Treatment of half headache ("Compendium of Gleanings"): Sichuan pepper five money, stinking sycamore leaves two two. First of all, the tung g-r fried yellow, the second into the pepper and then fried to fire wine sprinkled in the pot, mix and take up, rolled in silk, tied in the pain; eat a bowl of hot wine, take the cover neck and sleep, sweating.

Itchy eczema or prickly heat ("Shanghai Commonly Used Chinese Herbs"): appropriate amount of this product, decoction bath.

(E) Side effects of stinking sycamore

Toxicity

This product is not toxic. Dogs orally ingested water decoction 20 g / kg _ above caused vomiting, 10 g / kg below without vomiting, 10 g / kg per day for 3 weeks, liver function (B.S.P. clearance test), blood, electrocardiogram, and heart, liver and kidney pathology did not show any significant changes. Rats were gavaged with 0.25-2.5 g/kg of the heat-impregnated dosage per day*** for 60 days, and there was no serious toxicity except for the increase in the amount of water consumed by some of the rats, the decrease in activity, and the thinning of the stools. Intravenous injection to mice, heat dipping agent LD50 is l9.4 g / kg, put forward 0.98 / kg. To rats by gavage, hot dip l50 g / kg, put forward l7 g / kg (equivalent to 300 g / kg of raw drugs), no deaths were seen within 12 hours. A few cats in the test found hematuria, proteinuria, may have some effect on the kidney.

Usage and dosage

Internal: decoction, fresh 1-2 taels; or pounded juice. External use: pounding compress.

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