Urticaria is a stubborn skin disease. Every autumn is a period of high incidence, with recurrent attacks and severe itching of the skin, especially at night, which affects normal sleep.
The causes of urticaria mainly include the following aspects.
1, gourmet. Such as fish, shrimp, eggs, milk, followed by meat and plant food. Pigments, flavoring agents, preservatives, natural or synthetic substances in food can also cause urticaria.
2. Drugs.
3. infection.
Step 4 inhale. Pollen, dust, animal dander, smoke, feathers, fungal spores, volatile chemicals, etc.
5. Physical factors. Such as cold, heat, sunlight, friction and pressure.
6. Animal and plant factors. Such as insect bites, poisonous burrs, contact with nettles and wool.
7. Mental factors. The release of acetylcholine is caused by mental stress or excitement and exercise.
8. Genetic factors.
9. Visceral and systemic diseases.
Immune mechanism of urticaria: urticaria is a typical IgE-mediated type, which is caused by degranulation of mast cells mediated by IgE and release of inflammatory mediators such as histamine. The increase of capillary permeability produces air masses. Erythema caused by vasodilation and itching caused by inflammatory mediators stimulating receptors. According to classical theory, antigen binds to specific IgE on the surface receptor of skin mast cells, which stimulates mast cells to release inflammatory mediators such as histamine. At present, the theory of IgE-mediated autoimmune diseases is the most widely studied on the pathogenesis of chronic urticaria. There is sufficient evidence to prove that most patients with urticaria have functional anti-IgE receptor antibodies and anti-IgE antibodies that can degranulate skin mast cells or basophils. Serum total IgE is higher than normal, or eosinophils or neutrophils are higher. Through the examination of skin tissue extract, it was found that histamine levels in rash and non-rash areas increased, and histamine releasing factor could activate mast cells and basophils to release histamine.
It is scientifically proved that the IgE immunoglobulin in the immune system of patients with urticaria is 1- 10 times higher than that of normal people. These higher IgE will disturb the immune system of human body, make it sensitive, and lead to urticaria, thus strengthening the immune defense function of urticaria and improving its adaptability to the environment.
How should urticaria be treated?
1, avoid allergens
Urticaria patients will get sick as long as they are exposed to allergens, and paying more attention in a day can avoid allergens. When the symptoms are obvious, look at the surrounding environment and objects. If every occurrence is related to a fixed substance and environment, it may be an allergen.
2. recuperate allergic constitution and reduce IgE.
At present, doctors with urticaria will instruct them to take antihistamines, and if the condition is serious, they will use hormone drugs appropriately. However, drugs can only delay the onset of diseases and cannot fundamentally regulate allergic constitution. China Internal Medicine (Immune System Diseases): Urticaria is mostly caused by allergic mechanism. Allergens in food (mostly foreign proteins) stimulate the human body, causing the human body to produce specific antibody IgE (immunoglobulin E), which is attached to mast cells or basophils in the body. When eating this food again, IgE antibody will combine with allergens in the food, thus making mast cells and basophils release histamine. Histamine also acts on blood vessels, dilating blood vessels and increasing permeability, so a large amount of protein and liquid seep into skin tissue, resulting in urticaria.
From the immunology of urticaria, the fundamental treatment should be to control IgE and adjust the balance of immunoglobulin. The treatment of intestinal probiotics focuses on adjusting internal constitution, improving allergic symptoms, effectively inhibiting the abnormality of IgE immunoglobulin, reducing allergen-induced IgE production, and finally playing a role in preventing and treating urticaria. How to reduce IGE value and balance immunoglobulin? The World Health Organization (WHO) pointed out in its Guiding Opinions on the Treatment of Allergic Diseases that supplementing Xinminkang anti-allergic probiotics is a kind of health therapy that can radically cure allergic constitution. Xinmin Kang's anti-allergic probiotics include six patented strains: Lactobacillus Roy, lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus salivarius and Streptococcus thermophilus. By contacting with a special cell in the intestine, the scientifically matched patented strain activates the cell to produce a series of physiological reactions, and finally reduces the antibody immunoglobulin IgE in human blood, fundamentally regulates allergic constitution, enhances immunity, and thoroughly treats allergic diseases. After taking Xinmin Kang and fixing it on intestinal mucosa, it can promote the secretion of interferon (IFN-Y), regulate TH 1 immune response, inhibit immunoglobulin IgE, and improve the allergic phenomenon of TH2 immune response. Reduce the production of specific IgE antibody in serum; Adjust allergic constitution, inhibit allergic reaction and prevent allergic recurrence; Adjust immune system, balance and enhance immunity.
Don't use antipruritic drugs casually.
There are many urticaria patients who are prone to itching due to excessive sweating in summer. When itching occurs, they use antipruritic drugs casually. Some drugs are only temporary, and the antipruritic effect will appear again after it, and it will be more serious. Therefore, you can't use drugs casually. If there is itching or slight abnormality, you should consult a doctor in time and let the doctor help you treat it to prevent urticaria from recurring.
4. Daily prevention
The cause of urticaria is also directly related to our living habits. For example, in terms of diet, eating fish, shrimp, seafood or some foods with more artificial colors will directly lead to urticaria. Pay attention to hygiene in your daily diet and don't use those processed foods often. Don't take a sea bath or a cold bath often, but pay attention to your warmth. Don't smoke and drink often, including the drugs we use will directly induce urticaria.