Mainly used in the treatment of pernicious anemia, also used in combination with folic acid for the treatment of various megaloblastic anemia, anemia caused by antifolate drugs and steatorrhea, total gastrectomy or major gastrectomy. It is also used in neurological disorders (such as neuritis, neural atrophy, etc.) and liver diseases (hepatitis, cirrhosis).
Drugs that can interact with vitamin B12:
1. Combination with chloramphenicol should be avoided, otherwise it can counteract the hematopoietic function that vitamin B12 has.
2. In vitro test found that vitamin C can destroy vitamin B12, when given at the same time or long-term intake of vitamin C in large quantities, it can make the vitamin B12 blood concentration decreased.
3. Aminoglycoside antibiotics, p-aminosalicylic acid, phenobarbital, phenytoin sodium, paracetamol and other anticonvulsants and colchicine can reduce the absorption of vitamin B12 from the intestine.
4. Kaurenzamine binds vitamin B12 and reduces its absorption.
5. Combined with folic acid, it has a synergistic effect, and the two together can treat megaloblastic anemia.
Expanded Information:
Precautions for taking vitamin B12:
1. Hyperuricemia may occur with the use of this product in patients with gout.
2. This product can cause allergic reactions, even anaphylactic shock, and should not be abused.
3. The use of vitamin B12 in children with gout may induce gout.
4. In the treatment of megaloblastic anemia, it is advisable to check the blood potassium in the first 48 hours, so as to avoid bleeding and now severe hypokalemia.
5. Neurological damage, before the diagnosis is not clear, should not apply vitamin B12, so as not to mask the clinical manifestations of subacute combined degeneration.
6. Vitamin B12 deficiency can be accompanied by folic acid deficiency, such as intentional vitamin B12 treatment, although the blood can be improved, but can mask the clinical manifestations of folic acid deficiency. For this type of patients, it is advisable to supplement folic acid at the same time, in order to achieve a better therapeutic effect.
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