Joint and muscle pain is one of the early clinical manifestations of lupus erythematosus. About 95% of patients will develop joint pain (arthritis) at some point in the course of the disease, and 70% of patients with lupus erythematosus have joint and muscle pain as the initial clinical manifestation of the disease. Joints show flushing, increased surface temperature, and edema. Morning stiffness is usually evident.

Two, skin damage is also an early clinical manifestation of lupus erythematosus. The vast majority of patients with lupus erythematosus have skin lesions, which are an important basis for diagnosis, with the exception of butterfly-shaped erythema appearing on the cheeks bilaterally and plaques across the bridge of the nose.

Three, early clinical signs of lupus erythematosus also include fatigue and weakness. About 90 percent of people with lupus erythematosus experience mild to severe fatigue. But even in mild cases, patients are unable to engage in self-care and exercise in daily life. Increased fatigue and weakness is a typical premonitory sign of a lupus flare (relapse).

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