In the reaction of naproxen with sodium hydroxide, one H of naproxen is replaced by Na, which combines with OH to form water.
Naproxen is white or white-like crystalline powder; Tasteless or almost tasteless. Soluble in methanol, ethanol or chloroform, slightly soluble in ether, almost insoluble in water. Mainly suitable for rheumatoid arthritis, gout and other diseases. It is an over-the-counter drug and is included in medical insurance. The drug has cross-allergic reaction with non-steroidal anti-inflammatory drugs such as aspirin, which can strengthen the anticoagulant effect of dicoumarin. Long-term use is well tolerated, and the main side effects are mild and temporary discomfort in gastrointestinal tract.