Mandy Patinkin was born in an American middle-class family, with Russian, Polish and Jewish ancestry, and was a conservative Jew. Mandy Patinkin's mother is a housewife and her father works in a metal iron and steel smelting company in the United States. My mother once wrote a Jewish cookbook, Doralie's Jewish home cooking. Patinkin's cousin Mark Patinkin is a famous American columnist, and another cousin Sheldon Patinkin is the founder of the famous comedy group "Second City".

From 65438 to 0970, Mandy Patinkin graduated from Jianwu Middle School in Chicago and entered the University of Kansas. In college, Patinkin and Kelsey Grama were classmates. In an actor selection, Patinkin also put Granmo's name before himself.