First of all, isosorbide dinitrate and isosorbide mononitrate belong to nitrate anti-angina drugs. There is no difference in indications, pharmacological effects, adverse reactions and medication precautions. They are all used for long-term treatment of coronary heart disease, prevention of angina pectoris and treatment of persistent angina pectoris after myocardial infarction. The efficacy is the same, there is no difference between good and bad.

Their difference lies in the mechanism of action.

Isosorbide nitrate is metabolized into isosorbide mononitrate in vivo, which releases nitric oxide to activate guanylate cyclase, relax vascular smooth muscle and dilate peripheral arteries, especially veins.