Nearly one-third of the hundreds of uremic patients treated every year are caused by poor medication. In particular, more and more people are suffering from uremia caused by the application of traditional Chinese medicine. For a long time, people think that western medicine has great toxic and side effects, and Chinese medicine is mostly natural and has no toxic and side effects, so it is very common to take Chinese medicine blindly for a long time. For example, in the early 1990s, Chinese herbal medicine was popular in foreign countries for a while. Although some young women who took diet pills containing Chinese herbal medicine for a long time had a good weight loss effect, some people developed progressive renal failure, leading to uremia. Foreign scholars first put forward the concept of Chinese herbal medicine nephropathy, which attracted people's attention to the nephrotoxicity of Chinese herbal medicine. First, Chinese herbal medicine itself has nephrotoxicity. Toxins contained in Chinese herbal medicines directly or indirectly cause renal tubular injury and necrosis. For example, aristolochic acid contained in Akebia manshuriensis can cause swelling and shedding of some renal tubular epithelial cells, infiltration of a large number of inflammatory cells in renal interstitium, and ischemia of renal small vessel walls. Second, allergic reactions caused by Chinese herbal medicines. Under the special reaction state of the body, some Chinese herbal medicines can be used as allergic substances and enter the human body to cause systemic allergy, thus causing local acute allergic interstitial nephritis. Three, drug overdose or long-term application of drug accumulation caused by renal damage. Excessive use of some Chinese herbal medicines will lead to serious kidney damage. Fourth, the frying method is improper. Some Chinese herbal medicines have special requirements for decocting time, which must be strictly implemented. For example, Radix Aconiti Lateralis Preparata and Radix Tripterygii Wilfordii need to be decocted for a long time, and the side effects decrease with the prolonged decocting time, while the toxic side effects of Radix Sophorae Tonkinensis increase with the prolonged decocting time; Aluminum pot, iron pan and other decoctions can also increase toxicity because of improper utensils. Chinese herbal medicines with nephrotoxicity, such as Akebia Akebia, Tripterygium Wilfordii, Mylabris, Gallbladder, Kusnezoff monkshood, Scolopendra, Fel Sus Domestica, Gossypol, Motherwort, Stephania Tetrandra, Magnolia Officinalis, Xanthium sibiricum, Acacia, Semen sojae atricolor, Fructus Jiangnan, Bulbus Fritillariae Thunbergii, Rhizoma homalomenae, Cortex Meliae, Rhizoma Menispermi, Radix Trichosanthis, Semen Pharbitidis, Boat-fruited Sterculi Platycladus orientalis leaves, Psoralea corylifolia, garlic, areca nut, cubeba, cinnamon, clove, Bupleurum, HEMEROCALLIS HEMEROCALLIS root, Folium Isatidis, Syzygium bungeanum, Hippocampus, Brucea javanica, LYSIMACHIA, Flos Daturae, Lithargyrum, Plumbum preparatium, Radix Dioscoreae Bulbifera, Radix Hedyotis, Flos Daphne genkwa, and Radix Rhododendri. (Sun Yi, Yan Hong) Dr. He suggested that although Chinese herbal medicines have nephrotoxicity, most of them can reduce or eliminate their nephrotoxicity in the mixture (such as Chinese herbal medicine prescription) or after decoction, especially common Chinese medicines such as Leonurus japonicus, Stephania tetrandra, Magnolia officinalis, black beans, raw honey, Alisma orientalis, Polygonum cuspidatum, Psoralea corylifolia, garlic, Folium Isatidis and hippocampus. Generally, nephrotoxicity is easy to occur when a drug is taken for a long time and singly, so just pay attention to avoid it.