According to the query 39Health.com, tetrodotoxin is generally destroyed under high temperature, and it generally needs to be boiled for about 40 minutes, but the specific time needs to be judged according to the type of puffer fish. Tetrodotoxin is a neurotoxin mainly found in the liver, ovaries, blood and muscles of puffer fish, which may lead to food poisoning, dizziness, nausea, vomiting, abdominal pain, diarrhea and other symptoms if consumed. In general, if the puffer fish is cooked with frozen puffer fish, it can usually be cooked for about 40 minutes to partially remove the toxin from the puffer fish, but if it is cooked with heat, it usually needs to be cooked for a longer period of time in order to partially destroy the toxin from the puffer fish. It should be noted that if patients consume non-toxic puffer fish, they can usually consume it normally without undue concern. However, patients are advised to pay attention to the proper amount of puffer fish when consuming puffer fish so as not to aggravate the burden on the gastrointestinal tract and cause discomfort such as abdominal distension and abdominal pain. In addition, if the patient suffers from food poisoning after consuming puffer fish, it is recommended to seek medical advice in a timely manner, and treatment can be carried out through gastric lavage and inducing vomiting. At the same time, patients can also follow the doctor's instructions to use vitamin K1, vitamin B6 and other drugs for treatment, to relieve the discomfort symptoms.