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One glass of wine a day and you can live to be ninety-nine?

Wine culture can be said to be an indispensable part of traditional Chinese culture, and many famous works are inseparable from the role of wine. "All the sages in ancient times were lonely, and only the drinkers left their names." "If you enjoy a glass of wine before your death, why do you need a thousand-year name after your death?" "Three cups and two cups of light wine, how can it defeat him when he comes late and the wind is rushing." Wu Song's Tips for Fighting Tigers Drinking, flirting between men and women is also inseparable from wine, and the cologne is even more exciting. In short, the universe is great in the wine, and the sun and the moon are long in the cup.

Today we are fortunate to live in a prosperous age. In the soil of traditional wine culture, a liquor stock worth 1,800 yuan has been born, and the trillion-dollar liquor company is no longer alone.

Let’s put aside the wine culture here and only talk about the health issues related to wine.

In various public places, we can mostly see signs saying "Smoking is harmful to health", but what about drinking? Are common sayings like "a glass of wine a day can help you live to ninety-nine" and "big wine hurts the body, but small wine makes you happy" really true?

There has been a lot of information analyzing the health benefits of regular drinking. I searched online and listed the following commonly touted benefits of drinking: Regular drinking can enhance heart function and slow down the heart. And powerful; it can enhance the elasticity of blood vessels and reduce the possibility of blood vessel rupture; it can enhance muscle strength, strengthen legs, feet, muscles and bones, and make joints flexible; it can promote human blood circulation and metabolism; it can eliminate symptoms of cardiac ischemia or lower blood pressure. ; Make the human body eliminate fatigue, feel happy, and relieve palpitation; drinking alcohol can reduce the accumulation of triglycerides and cholesterol on the arterial wall, and also reduce the chance of blood sugar converting into triglycerides; drinking alcohol can reduce the accumulation of abdominal fat in the human body and maintain The human body is beautiful; drinking alcohol can reduce the formation of blood clots and reduce the possibility of myocardial infarction; drinking alcohol can reduce the production of hormones, and excessive adrenaline can cause arterial vascular disease.

What is the truth?

The World Health Organization’s announcement is: Drinking alcohol is harmful to health. There are more than 200 diseases caused by drinking, and more than 3 million people die every year because of drinking.

Let’s first take a look at the schematic diagram of alcohol metabolism:

After ethanol enters the human body, it will generate acetaldehyde under the action of alcohol dehydrogenase (ADH), and then remove it from acetaldehyde. Hydrogenase (ALDH2) catalyzes the production of acetate. Blushing after drinking alcohol may be caused by a lack of enzymes in the body that metabolize ethanol, resulting in excessive accumulation of acetaldehyde in the body, and acetaldehyde can cause blood vessels to dilate and make the face flush.

If the gene that controls aldehyde dehydrogenase (ALDH2) is deleted, acetaldehyde, the intermediate metabolite of alcohol, cannot be converted into acetic acid. The long-term accumulation of excess acetaldehyde in the human body will increase the incidence of cancer. Research shows that nearly half of the people in China lack aldehyde dehydrogenase (ALDH2). Chen Zhehong said that taking a population survey in Taiwan Province as an example, the ALDH2 gene deletion rate is about 47%, ranking highest in the world.

Let’s take a look at two blockbuster studies published in the top international magazine “Nature” in recent years. On January 3, 2018, Juan I. Garaycoechea and others published an article showing: Metabolites of alcohol Acetaldehyde can cause a large number of hematopoietic stem cell mutations. Mice carrying a defective ALDH2 gene had four times the number of DNA mutations after consuming alcohol compared to controls.

On January 3, 2018, Skrott et al.’s paper showed that drinking alcohol is carcinogenic.

Recently, a study of more than 10 million Koreans was published in a European magazine, specifically investigating the drinking situation. Compared with the incidence of atrial fibrillation, people who drink every day are more likely to drink alcohol than those who drink twice a week. Atrial fibrillation increased by more than 40, but there was no risk of atrial fibrillation without drinking alcohol.

How about drinking less alcohol? Didn't you say that drinking wine makes you happy?

In 2004, an Italian scholar published a survey document. He summarized 14 diseases and injuries such as drinking and tumors published in the past thirty years. The results found that even consuming as little as 25 grams of alcohol per day can increase the risk of a variety of diseases.

The risk of oral and pharyngeal cancer increases by 82, laryngeal cancer by 43, esophageal cancer by 39, chronic pancreatitis by 34, breast cancer by 25, liver cirrhosis by 1.9 times, etc.

The National Institutes of Health (NIH) in the United States urgently stopped a clinical trial to prove that drinking a small amount of alcohol every day is good for health, because two-thirds of the US$100 million required for the trial were from various sources. The one provided by the big winery... is soft-spoken and short-handed. How convincing can the test produced by this method be?

Therefore, no matter whether you drink a lot of wine or a small amount of wine, as long as you drink it regularly, it is harmful to your health. A few years ago, in the world-famous medical journal "The Lancet", the Global Burden of Disease Study Group found that drinking alcohol cannot bring any health benefits, and the idea that moderate drinking is beneficial simply does not exist! Moreover, alcohol consumption is one of the leading causes of death among young and middle-aged men (15-49 years old) worldwide!

People who smoke and drink in life often refute that there are many people who drink and smoke who live to be eighty or ninety years old, and there are also many people who do not smoke or drink who only live to be sixty or seventy years old. Here we must understand the fact that a human body's health or longevity is largely determined by its own genes, followed by acquired living habits and medical and health conditions. This involves the vertical comparison of the human body itself, or the horizontal comparison with others. We should compare with our own, not with others. Just as some cars are Lexus, some cars are domestic QQ. It's the same car, but the quality once it leaves the factory is incomparable. But the same car will naturally have different lifespans if it is carefully maintained or casually worn out.

If Mr. Gu Long didn’t drink, I don’t know how many martial arts masterpieces would come to the world, sigh!

Drinking and singing, what is life like? Answer: There is not much to come.