Hedyotis diffusa is the whole grass of Hedyotis diffusa (Willd.) Roxb. of Rubiaceae. Produced in Fujian, Guangxi, Guangdong, Yunnan, Zhejiang, Jiangsu, Anhui and other provinces. Harvest in summer and autumn and wash. Or dried, cut into sections, and used raw. The medicine is slightly bitter, sweet and cold. Meridian of stomach, large intestine and small intestine. Efficacy of clearing away heat and toxic materials, diuresis and stranguria. Use1.carbuncle swelling and sore poison, sore throat, poisonous snake bite. This product is bitter and cold, and has a strong effect of clearing away heat and toxic materials. It can be used for treating various syndromes caused by heat toxin, both orally and externally. For the treatment of carbuncle, swelling, sore and toxin, it can also be used together with honeysuckle, forsythia and chrysanthemum indicum. For abdominal pain due to intestinal carbuncle, it is often used with drugs such as Sargentodoxa, Patrinia scabiosaefolia and Peony bark. For sore throat, it is usually combined with herbs such as Scutellaria baicalensis Georgi, Scrophularia and Banlangen. If it is used to treat poisonous snake bites, it can be taken orally with fresh mashed juice or decocted in water, and the residue is applied to the wound, which has a good curative effect. It can also be used in combination with herbs such as Scutellaria barbata, Viola yedoensis and Paridis. In recent years, this product has been widely used in the treatment of various cancer syndromes by its function of clearing away heat and toxic materials and reducing swelling. 2. The heat is astringent and painful. This product is sweet and cold, and has the effect of clearing heat, promoting diuresis and treating stranguria. It is used alone to treat damp-heat in bladder, astringent and painful urination, and is often used with Imperata rhizome, Plantago asiatica and Pyrrosia. In addition, this product can clear heat and promote diuresis, and can also be used for damp-heat jaundice. Usage and dosage: decocted,15 ~ 60g. Appropriate amount for external use. Pay attention to the use of yin gangrene and spleen and stomach deficiency and cold. Modern research1.Chemical composition: This product contains triacontane, stigmasterol, ursolic acid, oleanolic acid, β-sitosterol, β-sitosterol -D- glucoside, p-coumaric acid, etc. 2. Pharmacological action: This product has a weak inhibitory effect on Staphylococcus aureus and Shigella dysenteriae in vitro; In vivo, it can stimulate the proliferation of reticuloendothelial system, promote the formation of antibodies, and enhance the phagocytosis of reticulocytes and leukocytes, thus achieving the purposes of antibacterial and anti-inflammatory; This product has obvious therapeutic effect on experimental appendicitis in rabbits, which can reduce body temperature and white blood cells and absorb inflammation. Its crude preparation has inhibitory effect on Ehrlich ascites carcinoma, Yoshida sarcoma and various leukemia cancer cells in vitro, but experimental treatment has no obvious anticancer effect. Intraperitoneal injection of Hedyotis diffusa liquid into mice can have analgesic, sedative and hypnotic effects; It also has the effects of inhibiting spermatogenesis and protecting liver and gallbladder. 3. Clinical research: It is reported that Hedyotis diffusa can be used for many diseases, such as: this product is combined with American ginseng, Ganoderma lucidum, Astragalus membranaceus, raspberry and other drugs to treat chronic hepatitis B 132 cases, and all of them have achieved good results; In addition, 98 cases of chronic hepatitis B were treated with this product, Polygonum cuspidatum, Radix Isatidis, Rhizoma Polygonati and Radix Astragali in combination with western medicine, and the total effective rate was 94.9% (Shizhen Traditional Chinese Medicine and National Medicine 2000,12:140). If the extract of this product (mainly flavonoids) is made into intravenous drip and combined with chemotherapy to treat 9 cases of non-lymphocytic leukemia/KLOC-0, the effective rate is 94.7% (Journal of Henan Traditional Chinese Medicine 200 1, 4: 38); 86 cases of precancerous lesions of chronic atrophic gastritis were treated with this product, which was mainly used according to the syndrome differentiation of clinical symptoms and decocted in water at 9~ 10 in the morning and 3~4 in the afternoon. The total effective rate was 85.88%. This product can also be used as tea without toxic side effects after long-term use (Fujian Traditional Chinese Medicine 200 1, 3: 37). 304 cases of infectious diseases such as pneumonia, cholecystitis, simple appendicitis and pelvic inflammatory disease were treated by intramuscular injection of 4ml of this product twice a day, and the total effective rate was 92.22% (journal of practical traditional chinese internal medicine 1 998,2:19). In modern times, this product has been widely used in esophageal cancer, gastric cancer, rectal cancer, liver cancer, cervical cancer, choriocarcinoma, bladder cancer, nasopharyngeal cancer, lung cancer, lymphosarcoma and leukemia by its detoxification and detumescence, and its clinical symptoms can be improved or basically disappeared (Herbal Medicine for Anti-cancer Treatment1994: 265). In addition, it is recorded that this product can also be used for rheumatoid arthritis, chronic nephritis, recurrent stomatitis, epididymal stagnation and acne. 4. Adverse reactions: when the dosage of this product is 30~60g, no obvious toxicity and side effects are found, and some cases have dry mouth after continuous medication; Large dose intravenous injection of its injection can slightly reduce the number of white blood cells and return to normal after withdrawal. Occasionally, allergic reactions such as red papules and dyspnea were relieved after stopping taking the drug.