Aspartame is a sugar substitute, sweet flavor almost no calories and carbohydrates, the sweetness of sucrose 150 to 200 times. The taste is pure, cool and refreshing like sucrose, but the sweetness is about 200 times of sucrose, and the calorie is only 1/200 of sucrose, which does not produce dental caries, does not affect the blood sugar, and does not cause obesity, high blood pressure, and coronary heart disease. It has been approved for use in more than 100 countries and regions in the world, and is widely used in all kinds of beverages, candies, food, pharmaceutical preparations and health products. Important nutraceuticals sweet additives

Aspartame and penicillin, it is also accidentally discovered. 1965 U.S. scientists in the study of drugs for the treatment of ulcers, accidentally found that the drugs he used have a strong sweet taste, so the U.S. Food and Drug Administration immediately launched a number of studies on this substance, and finally approved the commercialization. Because of its sweetness but low dosage and low calorie content, aspartame is widely used in food processing and is also sold as sugar packets on the market. Aspartame is used as a sweetener in cola, which is labeled as low-calorie, and in chewing gum, which prevents tooth decay. Aspartame is widely used by diabetics because it does not increase blood glucose levels when consumed. However, aspartame should not be used by patients suffering from the rare phenylketonuria because those with this genetic disorder cannot metabolize phenylpropionic acid, a substance found not only in aspartame but also in protein foods such as chicken, milk and vegetables.

Since aspartame is hydrolyzed in the body to release not only phenylalanine aspartic acid, but also methanol (methanol is an industrial alcohol and a possible ingredient in fake wine that can be metabolized in the body to formic acid and harm the body), its safety has been questioned.

Scholars at the European Ramazzini Foundation Institute for Independent Cancer Research in Bologna, Italy, say they have long studied aspartame with more than 1,800 house mice. They presented their findings at an international symposium in Italy. The researchers of this research society said that they found through their research that if the female house mouse consumes the same amount of aspartame as a human being consumes every day, then it has a very high chance of developing cancer, and the researchers said that these house mice that consume a certain amount of aspartame every day are mainly likely to develop brain cancer, kidney cancer and peripheral nerve cancer. Because aspartame is a major ingredient in many children's foods, the danger may be even greater for children. Pregnant women who consume aspartame-containing foods or take medicines containing the ingredient may also experience adverse health and fetal effects due to their weakened immune systems.

The study pointed out that due to the extremely low dosage of aspartame, the ingestion of very small amounts of methanol is not harmful to the human body. In addition, there is some question as to whether the aspartic acid in aspartame could cause brain damage, endocrine disruption or tumors, when in fact more aspartic acid (which is also part of protein) is consumed from the general diet. So although it is questionable, it is also thought to cause no major harm because of the low intake of aspartame.

The U.S. FDA's permissible daily intake of aspartame is 50 milligrams per kilogram of body weight, while in Europe it is 20 milligrams per kilogram of body weight, and there are no domestic standards for it. A can of easy-open (355ml) low-calorie drinks contain about 180mg of aspartame, and commercially available aspartame sugar packets contain even less. Aspartame is currently permitted as a food additive in more than 90 countries around the world.

The biggest disadvantage of aspartame is that it has low stability and is easily damaged by acidity, alkalinity and temperature. As soon as it is heated, aspartame will be decomposed and lose its sweetness, so aspartame is only suitable to be added to cold beverages and ices.

To summarize: zero degrees of Coca-Cola can still drink, but it is still recommended to remember to drink less, what to eat more are not good.