The bioavailability of this product ranges from 3-5%. It is rapidly absorbed through the nasal mucosa and peak plasma concentrations are reached within 1 hour of administration (median time approximately 10 minutes). The plasma clearance half-life is approximately 20 minutes and there is no cumulative effect of multiple doses. Administration of higher than recommended doses will result in increased blood concentrations (as evidenced by an increase in the area under the drug-time curve) without a concomitant increase in relative bioavailability. As with other peptide hormones, monitoring the blood concentration of salmon calcitonin is of little significance because it is not a direct predictor of its therapeutic effect. Therefore, clinical efficacy parameters should be used to assess the efficacy of this product.