Only if the probiotics reach the intestines alive can they work. It is generally recommended to take it about twenty minutes after a meal, because the concentration of stomach acid is too high before the meal, which will make the probiotics inactive. After the food neutralizes the stomach acid, the probiotics can reach the intestines more smoothly and can better improve the intestinal microecology. If you're working late at night, you can eat lifespace probiotics to supplement your probiotics.