1. Breast lump: It is the most common manifestation of breast cancer. 2. Nipple changes: Nipple discharge is mostly benign changes, but those over 50 years old with unilateral nipple discharge should be alert to the possibility of breast cancer; nipple depression; nipple itching, desquamation, erosion, ulcers, scabs, etc. Eczema-like changes are often a clinical manifestation of Paget's disease of the breast. 3. Breast skin and contour changes: Tumor invades Cooper's ligament of the skin, which can form a "dimple sign"; tumor cells block subcutaneous lymphatic capillaries, causing skin edema, and depressions in hair follicles form an "orange peel sign"; when the skin is extensively invaded Sometimes, many hard nodules or small cords can form on the epidermis, or even merge into sheets. If the lesions extend to the back and contralateral chest wall, breathing can be restricted and armored thyroid cancer can form. In inflammatory breast cancer, the breasts will be significantly enlarged. The skin becomes congested, red and swollen, and the local skin temperature increases; in addition, advanced breast cancer may cause skin rupture to form cancerous ulcers. 4. Lymph node enlargement: The ipsilateral axillary lymph node can be swollen, and advanced breast cancer can metastasize to the contralateral axillary lymph node and cause swelling; in addition, in some cases, enlarged ipsilateral and or contralateral supraclavicular lymph nodes can also be touched.