Can be used for treating degenerative joint diseases (osteoarthritis and related diseases). Renal insufficiency will affect the pharmacokinetics of diacerein. In this case, it is suggested to reduce the dose (creatinine clearance rate < 30 ml/min). Taking diacerein after meals can improve its absorption rate (about 24%); On the other hand, severe malnutrition will reduce the bioavailability of diacerein. The incidence of side effects (such as accelerating intestinal transport) is directly related to the unabsorbed amount of diacerein, which will increase when fasting or eating less. Laxatives should not be taken at the same time as ambidine. It is forbidden to use drugs that improve the properties of intestinal transport and/or intestinal contents. In order to improve the bioavailability of diacerein, drugs containing aluminum hydroxide and/or magnesium hydroxide should be avoided.