The liver is the most prone to distant metastasis of pancreatic neuroendocrine tumors. In addition, some studies have pointed out that the liver is the most prone to distant metastasis of neuroendocrine tumors. This metastasis mode is called M 1 type, that is, it only transfers to the liver.

However, the liver is the most common distant metastasis site, not all PNET will metastasize to the liver, but also other sites such as lung, ovary, distant lymph nodes, peritoneum and bone.