Atherosclerosis of the lower limbs can be divided into light and heavy, and severe arteriosclerosis and occlusion of the lower limbs will be caused, mainly due to the formation of atherosclerotic plaques of the lower limbs, which will lead to stenosis and occlusion of the lower limbs and chronic ischemia of the limbs. The treatment of this situation is mainly to dilate blood vessels and improve blood supply treatment. In drug treatment, the commonly used drugs mainly include alprostadil, which can improve circulation. To quit smoking, because smoking is closely related to ischemic diseases of lower limbs, strengthening physical exercise and regular walking exercise can obviously alleviate the symptoms of most patients. In the aspect of medication, besides alprostadil, drugs for lowering blood lipid can also be used, such as atorvastatin, rosuvastatin and phenylZabyti. Taking antihypertensive drugs, many of them are complicated with hypertension, so it is necessary to control blood pressure to normal. Surgical treatment is effective for severe arteriosclerosis obliterans of lower limbs.